Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 7/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319733 | 0.93 | POLB (0.48) | POLBKCNH2KCNJ1DRD2DRD3 | |
| SCHEMBL5316522 | 0.89 | POLB (0.43) | POLBKCNH2KCNJ1DRD2DRD3 | |
| SCHEMBL5317453 | 0.88 | KMT2A (0.48) | POLBKCNH2KCNJ1DRD2DRD3 | |
| SCHEMBL5316699 | 0.88 | CA1 (0.44) | POLBKCNH2KCNJ1CHRNA7CA1 | |
| SCHEMBL5331515 | 0.88 | LMNA (0.50) | POLBKCNH2DRD2HTR1ACA1 | |
| SCHEMBL5314874 | 0.87 | POLB (0.54) | POLBDRD2HPGDHTR1AROCK2 | |
| SCHEMBL5315867 | 0.85 | ERCC1 (0.44) | POLBKCNH2KCNJ1DRD2DRD3 | |
| SCHEMBL5316954 | 0.84 | POLB (0.44) | POLBDRD2HPGDHTR1AIDO1 | |
| SCHEMBL5314570 | 0.83 | HTR1A (0.48) | POLBDRD2HPGDHTR1ACA1 | |
| SCHEMBL5315934 | 0.83 | MCHR1 (0.48) | POLBKCNH2DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |