Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316192 | 0.92 | HTT (0.52) | HTR1AHTR2ADRD2HTR7HTR6 | |
| SCHEMBL5319733 | 0.90 | POLB (0.48) | HTR1AHTR2ADRD2HTR7HTR6 | |
| SCHEMBL5316933 | 0.89 | KCNH2 (0.47) | HTR1AHTR2AHRH1DRD2HTR7 | |
| SCHEMBL5319103 | 0.89 | KCNH2 (0.49) | HTR1AHRH1DRD2HTR7HTR6 | |
| SCHEMBL5315856 | 0.88 | POLB (0.49) | HTR1AHTR2ADRD2HTR7HTR6 | |
| SCHEMBL5316850 | 0.88 | HTR1A (0.49) | HTR1AHTR2ADRD4HRH1OPRM1 | |
| SCHEMBL5319026 | 0.88 | HTR1A (0.49) | HTR1AHTR2ADRD4HRH1OPRM1 | |
| SCHEMBL5314874 | 0.87 | POLB (0.54) | HTR1AHTR2ADRD2HTR7HTR6 | |
| SCHEMBL5315877 | 0.86 | ABCB1 (0.48) | HTR1AHTR2ADRD4HRH1OPRM1 | |
| SCHEMBL5315867 | 0.85 | ERCC1 (0.44) | DRD2HTTUSP2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |