Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | CTSG | P08311 | 2/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.36 |
| ▸ | CMA1 | P23946 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8216557 | 0.72 | ALDH1A1 (0.42) | SLC6A2SLC6A3 | |
| SCHEMBL487448 | 0.69 | CTSK (0.49) | CTSKCTSSPRSS1CTSGCTRB1 | |
| SCHEMBL487446 | 0.69 | CTSK (0.49) | CTSKCTSSPRSS1CTSGCTRB1 | |
| SCHEMBL7061908 | 0.68 | CTSK (0.50) | CTSKCTSSPRSS1CTSGCTRB1 | |
| SCHEMBL28903387 | 0.66 | MMP2 (0.47) | CTSKCTSS | |
| SCHEMBL1914958 | 0.66 | CTSS (0.46) | CTSKCTSSPRSS1CTSGCTRB1 | |
| SCHEMBL1914954 | 0.66 | CTSS (0.46) | CTSKCTSSPRSS1CTSGCTRB1 | |
| SCHEMBL1915090 | 0.66 | CTSS (0.46) | CTSKCTSSPRSS1CTSGCTRB1 | |
| SCHEMBL9574193 | 0.66 | MMP2 (0.47) | CTSKCTSS | |
| SCHEMBL5707507 | 0.66 | METAP2 (0.58) | CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |