Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETDB1 | Q15047 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18300420 | 0.85 | GPR35 (0.39) | ENPP2ALDH1A1KMT2AGPR35EPHX2 | |
| SCHEMBL5315960 | 0.83 | ENPP2 (0.39) | ENPP2ALDH1A1KMT2AGPR35EPHX2 | |
| SCHEMBL25840301 | 0.80 | ALDH1A1 (0.50) | ALDH1A1NPSR1KMT2AEPHX2CYP1A2 | |
| SCHEMBL5318967 | 0.80 | SETDB1 (0.55) | SETDB1ENPP2EGLN2EPHX2 | |
| SCHEMBL18300223 | 0.79 | CTSS (0.41) | ENPP2EGLN2LMNA | |
| SCHEMBL10622670 | 0.74 | EGLN2 (0.41) | EGLN2ALDH1A1KMT2AGPR35 | |
| SCHEMBL14232838 | 0.73 | NPSR1 (0.53) | NPSR1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL17514852 | 0.73 | TTR (0.38) | ALDH1A1KMT2ALMNA | |
| SCHEMBL12845232 | 0.71 | TTR (0.39) | ALDH1A1KMT2AGPR35CYP3A4 | |
| SCHEMBL5315293 | 0.70 | LOXL2 (0.60) | SETDB1EGLN2ALDH1A1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280707-B1 | BICYCLIC QUINAZOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-12-20 | — | — | EP | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |