Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | TGM1 | P22735 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8522925 | 0.77 | SIGMAR1 (0.58) | DRD4SIGMAR1LMNAGAA | |
| SCHEMBL11667264 | 0.77 | MAPT (0.33) | MAPT | |
| SCHEMBL3804983 | 0.77 | — | — | |
| SCHEMBL4252810 | 0.77 | CHRNA7 (0.58) | CHRNA7DRD4KCNH2SIGMAR1DRD2 | |
| SCHEMBL27413682 | 0.74 | DRD2 (0.56) | CHRNA7DRD4KCNH2SIGMAR1DRD2 | |
| SCHEMBL175992 | 0.73 | CHRNA7 (0.58) | CHRNA7DRD4KCNH2SIGMAR1DRD2 | |
| SCHEMBL8313424 | 0.72 | MAPT (0.50) | CHRNA7DRD4KCNH2SIGMAR1DRD2 | |
| SCHEMBL576814 | 0.72 | LMNA (0.67) | CHRNA7DRD4KCNH2SIGMAR1DRD2 | |
| SCHEMBL385012 | 0.72 | — | — | |
| SCHEMBL576454 | 0.72 | LMNA (0.67) | CHRNA7DRD4KCNH2SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3090027-A | — | — | None | — | — | JP | disclosed |
| JP-3007266-A | — | — | None | — | — | JP | disclosed |
| US-20070299091-A1 | Azaindole Carboxamides | GMEINER PETER | 2007-12-27 | — | — | US | disclosed |
| EP-1771448-A1 | AZAINDOLE CARBOXAMIDES | SCHWARZ PHARMA AG (DE) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006050976-A1 | AZAINDOLE CARBOXAMIDES | SCHWARZ PHARMA AG (DE) | 2006-05-18 | — | — | WO | disclosed |
| US-5075308-A | Method for treating urinary obstruction | HITACHI CHEMICAL CO., LTD. (JP) | 1991-12-24 | — | — | US | disclosed |
| JP-H0390027-A | DYSURIA REMEDY | HITACHI CHEM CO LTD | 1991-04-16 | — | — | JP | disclosed |
| JP-H037266-A | 2-(4-PHENYL-1-PIPERAZINYLALKYL)AMINO-5-ETHYNYLPYRIMIDINE DERIVATIVE, ITS INTERMEDIATE AND PRODUCTION THEREOF | SHIRATORI SEIYAKU KK | 1991-01-14 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299091-A1 | Azaindole Carboxamides | TPH1, TPH2, HTR1A | CHRNA7 59/4885DRD4 94/4885KCNH2 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.