Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3491372 | 0.89 | HDAC1 (0.42) | DHODHGPR119UCHL1BRD3BRD4 | |
| SCHEMBL14387738 | 0.86 | HTR1A (0.39) | DHODHGPR119UCHL1KMT2ADRD2 | |
| SCHEMBL15493946 | 0.86 | F12 (0.46) | DHODHGPR119UCHL1KDM4EALDH1A1 | |
| SCHEMBL888599 | 0.83 | GPR119 (0.39) | DHODHGPR119UCHL1BRD3BRD4 | |
| SCHEMBL887712 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1LMNAHSD17B10KMT2A | |
| SCHEMBL14156402 | 0.81 | HSD17B10 (0.43) | KDM4EALDH1A1LMNAHSD17B10KMT2A | |
| SCHEMBL14356126 | 0.80 | RAB9A (0.37) | DHODHGPR119UCHL1BRD3KMT2A | |
| SCHEMBL16802301 | 0.79 | LEF1 (0.44) | KMT2A | |
| SCHEMBL20764331 | 0.79 | NOTUM (0.44) | KDM4EALDH1A1LMNAHSD17B10KMT2A | |
| SCHEMBL15493945 | 0.79 | BRD4 (0.46) | DHODHGPR119UCHL1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121667-B1 | CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF | SQUIBB & SONS LLC (US) | 2016-06-08 | — | — | EP | disclosed |
| EP-2121667-B1 | CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF | SQUIBB & SONS LLC (US) | 2016-06-08 | — | — | EP | disclosed |
| EP-1687609-B1 | FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND | EPOCH BIOSCIENCES INC (US) | 2014-12-10 | — | — | EP | disclosed |
| EP-1687609-B1 | FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND | EPOCH BIOSCIENCES INC (US) | 2014-12-10 | — | — | EP | disclosed |
| US-8664407-B2 | Chemical linkers with single amino acids and conjugates thereof | Medarex, LLC (US) | 2014-03-04 | — | — | US | disclosed |
| US-8664407-B2 | Chemical linkers with single amino acids and conjugates thereof | Medarex, LLC (US) | 2014-03-04 | — | — | US | disclosed |
| US-8664407-B2 | Chemical linkers with single amino acids and conjugates thereof | Medarex, LLC (US) | 2014-03-04 | — | — | US | disclosed |
| US-8465921-B2 | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders | ELITECH HOLDING B.V. (NL) | 2013-06-18 | — | — | US | disclosed |
| US-8461117-B2 | Chemical linkers and cleavable substrates and conjugates thereof | MEDAREX, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-8461117-B2 | Chemical linkers and cleavable substrates and conjugates thereof | MEDAREX, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-6426408-B1 | PLURALITY OF NUCLEOTIDE UNITS WITH LINKING GROUP | EPOCH BIOSCIENCES, INC. | 2002-07-30 | — | — | US | disclosed |
| US-20020052482-A1 | Covalently linked oligonucleotide minor grove binder conjugates | MICROPROBE | 2002-05-02 | — | — | US | disclosed |
| US-20020034754-A1 | Fluorescent quenching detection reagents and methods | ELITECHGROUP, INC. | 2002-03-21 | — | — | US | disclosed |
| US-6312894-B1 | HYBRIDIZATION OF OLIGONUCLEOTIDES AND MINOR GROOVE BINDER COMBINATION; WHERE THE MINOR GROOVE BINDER BINDS IN A NON-INTERCALATING MANNER WITH A HIGHER ASSOCIATION CONSTANT | EPOCH PHARMACEUTICALS, INC. | 2001-11-06 | — | — | US | disclosed |
| US-6143877-A | FORMING A TRIPLEX BY CONTACTING DUPLEX NUCLEIC ACID HAVING A TARGET SEQUENCE OF PURINE BASES WITH A OLIGONUCLEOTIDE HAVING AT LEAST ONE GUANINE BASE REPLACED BY 6-AMINO-1H-PYRAZOLO(3,4-D)PYRIMIDIN-4(5H)-ONE | EPOCH PHARMACEUTICALS, INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6084102-A | THE OLIGONUCLEOTIDE IS COMPLEMENTARY TO A TARGET SEQUENCE OF SINGLE STRANDED OR DOUBLE STRANDED DNA, RNA OR HYBRIDS AND, WHEN USED AS A PROBE, BINDS MORE STRONGLY BECAUSE OF THE BOUND MINOR GROVE BINDER; MEDICAL DIAGNOSIS; ANTISENSE THERAPY | EPOCH PHARMACEUTICALS, INC. (US) | 2000-07-04 | — | — | US | disclosed |
| US-5801155-A | Covalently linked oligonucleotide minor grove binder conjugates | EPOCH PHARMACEUTICALS, INC. (US) | 1998-09-01 | — | — | US | disclosed |
| CN-1186496-A | Covalently bound oligonucleotide minor groove binder conjugates | IBORCH PHARMACEUTICAL CORP (US) | 1998-07-01 | — | — | CN | disclosed |
| EP-0819133-A2 | COVALENTLY LINKED OLIGONUCLEOTIDE MINOR GROOVE BINDER CONJUGATES | EPOCH PHARMACEUTICALS, INC. (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996032496-A2 | COVALENTLY LINKED OLIGONUCLEOTIDE MINOR GROOVE BINDER CONJUGATES | MICROPROBE CORPORATION (US) | 1996-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052482-A1 | Covalently linked oligonucleotide minor grove binder conjugates | CD2BP2, MICA, SELPLG | DHODH 2763/4885GPR119 2142/4885UCHL1 2947/4885 |
| US-20020034754-A1 | Fluorescent quenching detection reagents and methods | DDX5, DDX21, DCLRE1B | DHODH 1111/4885GPR119 4229/4885UCHL1 2760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.