Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 4/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5327982 | 0.81 | CYP11B2 (0.50) | CYP11B2TRPV4EGLN2CYP11B1 | |
| SCHEMBL7406019 | 0.79 | AHR (0.50) | TDP1IDO1 | |
| SCHEMBL5330919 | 0.77 | CNR2 (0.44) | CYP11B2CYP11B1AR | |
| SCHEMBL5326735 | 0.77 | ALDH1A1 (0.47) | ARALDH1A1 | |
| SCHEMBL7815866 | 0.77 | AHR (0.43) | TDP1IDO1 | |
| SCHEMBL21084000 | 0.75 | CYP11B2 (0.56) | CYP11B2TRPV4EGLN2CYP11B1AR | |
| SCHEMBL4831885 | 0.75 | PTGS2 (0.42) | CASP1 | |
| SCHEMBL11516915 | 0.75 | CYP3A4 (0.53) | CASP1ALDH1A1TDP1 | |
| SCHEMBL5326424 | 0.74 | CYP11B2 (0.54) | CYP11B2TRPV4EGLN2CYP11B1AR | |
| SCHEMBL2465105 | 0.72 | TSHR (0.44) | CYP11B2ARALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |