Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 6/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | F11 | P03951 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322067 | 0.81 | PDE4A (0.50) | ALDH1A1KDM4EUSP2 | |
| SCHEMBL5329094 | 0.78 | KDM4E (0.40) | KDM4E | |
| SCHEMBL29123961 | 0.78 | MAOB (0.57) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL5330919 | 0.77 | CNR2 (0.44) | ARPGR | |
| SCHEMBL5326419 | 0.77 | CYP11B2 (0.44) | ALDH1A1AR | |
| SCHEMBL5327982 | 0.77 | CYP11B2 (0.50) | — | |
| SCHEMBL5321545 | 0.77 | PTGS2 (0.46) | ALDH1A1KDM4E | |
| SCHEMBL5326742 | 0.76 | ALDH1A1 (0.54) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL5327699 | 0.73 | AR (0.47) | IMPDH2IMPDH1ARMAOAMAOB | |
| SCHEMBL5326185 | 0.73 | AR (0.43) | ARPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |