Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 18/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 17/20 | 0.50 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5330919 | 0.87 | CNR2 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL5326419 | 0.81 | CYP11B2 (0.44) | CYP11B2CYP11B1TRPV4EGLN2 | |
| SCHEMBL1134830 | 0.79 | MAOB (0.38) | CYP11B2CYP11B1 | |
| SCHEMBL5326735 | 0.77 | ALDH1A1 (0.47) | — | |
| SCHEMBL18297999 | 0.76 | CYP11B2 (0.67) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL1514257 | 0.75 | CYP11B1 (0.78) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL30132416 | 0.75 | CYP11B1 (0.78) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL5326217 | 0.75 | ACHE (0.39) | — | |
| SCHEMBL9612021 | 0.74 | CYP11B2 (0.68) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL5327983 | 0.74 | CYP11B2 (0.58) | CYP11B2CYP11B1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |