Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11712273 | 0.77 | BACE1 (0.59) | KDM4EALDH1A1HTR2AHTR2CHPGD | |
| SCHEMBL19538924 | 0.74 | GPR3 (0.56) | KDM4EALDH1A1SMN1; SMN2TDP1HPGD | |
| SCHEMBL23986120 | 0.70 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2TDP1GFER | |
| SCHEMBL24856039 | 0.69 | ALDH1A1 (0.58) | KDM4EALDH1A1SMN1; SMN2TDP1GFER | |
| SCHEMBL11681291 | 0.67 | ALDH1A1 (0.53) | KDM4EALDH1A1SMN1; SMN2TDP1GFER | |
| SCHEMBL19531696 | 0.67 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2GFERHPGD | |
| SCHEMBL19969853 | 0.67 | HTR3A (0.42) | KDM4EALDH1A1SMN1; SMN2TDP1HPGD | |
| SCHEMBL4925728 | 0.67 | KMT2A (0.46) | KDM4EALDH1A1SMN1; SMN2TDP1GFER | |
| Ammonia Solution, Strong SCHEMBL27949259 | 0.66 | ALDH1A1 (0.52) | KDM4EALDH1A1SMN1; SMN2TDP1GFER | |
| SCHEMBL10654147 | 0.66 | PGR (0.55) | KDM4EALDH1A1TDP1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807427-A2 | SUBSTITUTED INDOLIZINES AND DERIVATIVES AS CNS AGENTS | Wyeth (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006050007-A2 | SUBSTITUTED INDOLIZINES AND DERIVATIVES AS CNS AGENTS | WYETH (US) | 2006-05-11 | — | — | WO | claimed |