Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19068171 | 0.84 | HTR3A (0.42) | HTR3AKDM4ESMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL19969811 | 0.73 | HTR3A (0.39) | HTR3AKDM4ESMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL19969987 | 0.71 | HTR3A (0.39) | HTR3AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL17170668 | 0.68 | HTR3A (0.57) | HTR3AALDH1A1LMNAMAPTCNR1 | |
| SCHEMBL5328061 | 0.67 | KDM4E (0.47) | KDM4ESMN1; SMN2ALDH1A1TDP1LMNA | |
| SCHEMBL17176479 | 0.67 | HTR3A (0.59) | HTR3ASMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL11681291 | 0.64 | ALDH1A1 (0.53) | KDM4ESMN1; SMN2ALDH1A1TDP1MAPT | |
| Ammonia Solution, Strong SCHEMBL27949259 | 0.62 | ALDH1A1 (0.52) | KDM4ESMN1; SMN2ALDH1A1TDP1MAPT | |
| SCHEMBL31081068 | 0.62 | LDHA (0.36) | KDM4ESMN1; SMN2ALDH1A1TDP1MAPT | |
| SCHEMBL10654147 | 0.62 | PGR (0.55) | KDM4EALDH1A1TDP1LMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072758-A1 | 5HT3 RECEPTOR ANTAGONISTS | TAKEDA CALIFORNIA, INC. | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072758-A1 | 5HT3 RECEPTOR ANTAGONISTS | HTR3A, HTR3B, HTR5A | HTR3A 1/4885KDM4E 3871/4885SMN1; SMN2 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.