SCHEMBL5329191

SCHEMBL5329191

[CH2]C(CCCC)Sc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PPARG P37231 14/20 0.46
PPARA Q07869 13/20 0.46
ALOX5 P09917 12/20 0.46
PTGES O14684 9/20 0.43
LMNA P02545 1/20 0.42
PAX8 Q06710 1/20 0.42
LTA4H P09960 1/20 0.36
PKM P14618 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CNR2 P34972 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11365097 0.80 ALOX5 (0.34) PPARGPPARAALOX5PTGESLMNA
SCHEMBL7975341 0.79 ALDH1A1 (0.40) PPARGPPARAALOX5LMNAPAX8
SCHEMBL1455005 0.78 PPARG (0.43) PPARGPPARAALOX5PTGESLMNA
SCHEMBL27826666 0.77 PPARG (0.42) PPARGPPARAALOX5PTGESLMNA
SCHEMBL8800266 0.77 PPARG (0.46) PPARGPPARAALOX5PTGESLMNA
SCHEMBL1453475 0.76 PPARG (0.41) PPARGPPARAALOX5PTGESLMNA
SCHEMBL7241349 0.74 LMNA (0.43) PPARGPPARAALOX5PTGESLMNA
SCHEMBL1455081 0.73 LMNA (0.42) PPARGPPARAALOX5PTGESLMNA
SCHEMBL809553 0.73 PPARG (0.43) PPARGPPARAALOX5PTGESLMNA
SCHEMBL9487592 0.73 MAOA (0.46) PPARGPPARAALOX5PTGESLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007119600-A1 CARBAZOLE COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 WO disclosed