Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 2/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534062 | 0.91 | ERAP1 (0.52) | ERAP1SMN1; SMN2LMNAMAPK1TSHR | |
| SCHEMBL533957 | 0.84 | TP53 (0.39) | ERAP1SMN1; SMN2HTTTSHRTP53 | |
| SCHEMBL532935 | 0.83 | ALDH1A1 (0.53) | SMN1; SMN2LMNAMAPK1TP53MEN1 | |
| SCHEMBL534065 | 0.82 | PKM (0.53) | ALPLSMN1; SMN2PKMKMT2A | |
| SCHEMBL14288678 | 0.82 | ALDH1A1 (0.52) | ALPLSMN1; SMN2LMNAMAPK1HTT | |
| SCHEMBL532832 | 0.81 | FFAR4 (0.60) | SMN1; SMN2LMNAHTTTSHRKEAP1 | |
| SCHEMBL533016 | 0.80 | ALPL (0.49) | ALPLERAP1TSHRTP53ALDH1A1 | |
| SCHEMBL533460 | 0.80 | ALDH1A1 (0.42) | ERAP1SMN1; SMN2LMNAMAPK1PKM | |
| SCHEMBL533017 | 0.79 | FFAR4 (0.55) | SMN1; SMN2LMNATP53MEN1KMT2A | |
| SCHEMBL532980 | 0.78 | JAK2 (0.48) | SMN1; SMN2LMNAPKMHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |