Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | EDNRB | P24530 | 2/20 | 0.50 |
| ▸ | EDNRA | P25101 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 2/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 3/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534062 | 0.89 | ERAP1 (0.52) | GAAKMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL532935 | 0.88 | ALDH1A1 (0.53) | GAAKMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL14288678 | 0.87 | ALDH1A1 (0.52) | BRD4KDM4EKMT2ASMN1; SMN2ALPL | |
| SCHEMBL533016 | 0.84 | ALPL (0.49) | BRD4GLAALPLTRIM24WDR5 | |
| SCHEMBL533112 | 0.83 | ALPL (0.46) | PKMKMT2AGLAALPLL3MBTL1 | |
| SCHEMBL532936 | 0.82 | MCOLN3 (0.51) | PKMKMT2ASMN1; SMN2ALPL | |
| SCHEMBL532832 | 0.81 | FFAR4 (0.60) | EDNRASMN1; SMN2ALOX15 | |
| SCHEMBL14288682 | 0.81 | ALPL (0.47) | KMT2AALPLWDR5 | |
| SCHEMBL533247 | 0.79 | CNR2 (0.39) | KMT2AWDR5 | |
| SCHEMBL532939 | 0.78 | EDNRA (0.43) | GAAEDNRBEDNRABRD4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |