Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 6/20 | 0.46 |
| ▸ | BRD1 | O95696 | 5/20 | 0.46 |
| ▸ | BRD4 | O60885 | 5/20 | 0.46 |
| ▸ | BRPF3 | Q9ULD4 | 4/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.46 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533137 | 0.87 | RXFP1 (0.50) | BRPF1BRD1BRD4HTR6MAPT | |
| SCHEMBL533017 | 0.86 | FFAR4 (0.55) | ALDH1A1MAPTRECQLKDM4ELMNA | |
| SCHEMBL533437 | 0.84 | CYTH2 (0.49) | ALDH1A1MAPTRECQLKDM4ELMNA | |
| SCHEMBL532880 | 0.84 | FFAR4 (0.56) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL533055 | 0.84 | ALDH1A1 (0.45) | HTR6ALDH1A1MAPTRECQLKDM4E | |
| SCHEMBL533666 | 0.84 | FFAR4 (0.56) | ALDH1A1MAPTRECQLLMNA | |
| SCHEMBL532776 | 0.84 | FFAR4 (0.54) | ALDH1A1MAPTRECQLLMNA | |
| SCHEMBL533091 | 0.82 | BRPF1 (0.52) | BRPF1ALDH1A1MAPTRECQLKDM4E | |
| SCHEMBL534077 | 0.82 | TSHR (0.47) | HSD11B1ALDH1A1MAPTRECQLLMNA | |
| SCHEMBL532953 | 0.82 | FFAR4 (0.59) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |