Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.33 |
| ▸ | CNR2 | P34972 | 7/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134854 | 0.79 | CNR1 (0.37) | CNR1CNR2KMT2APOLBKCNH2 | |
| SCHEMBL5135170 | 0.76 | OPRM1 (0.39) | CNR1CNR2OPRD1OPRM1POLB | |
| SCHEMBL5135169 | 0.64 | PARP1 (0.39) | CNR1CNR2OPRM1OPRL1 | |
| SCHEMBL5332677 | 0.64 | OPRL1 (0.33) | OPRL1 | |
| SCHEMBL3614449 | 0.63 | HPGD (0.49) | KMT2APOLBHSD11B1CYP2D6MEN1 | |
| SCHEMBL5135172 | 0.62 | OPRM1 (0.37) | CNR1CNR2OPRM1OPRL1 | |
| SCHEMBL1290783 | 0.61 | OPRM1 (0.35) | OPRM1KMT2AOPRL1 | |
| SCHEMBL12727293 | 0.59 | PKM (0.47) | CXCR2 | |
| SCHEMBL415193 | 0.58 | CYP2D6 (0.46) | POLBSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL5190868 | 0.58 | SLC6A4 (0.45) | SLC6A2SLC6A4SLC6A3HSD11B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053400-A2 | PIPERIDINE GLYCINE TRANSPORTER INHIBITORS | MERCK & CO., INC. (US) | 2007-05-10 | — | — | WO | disclosed |