Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059112 | 0.75 | CA12 (0.41) | MAOBKDM4EPKMTSHRALDH1A1 | |
| SCHEMBL10434959 | 0.73 | MAOB (0.41) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL379626 | 0.69 | MAOB (0.48) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL186955 | 0.69 | — | — | |
| SCHEMBL30484685 | 0.69 | — | — | |
| Chromanone SCHEMBL29384996 | 0.68 | MAOB (0.56) | MAOBADORA3ARKDM4ECYP19A1 | |
| Formaldehyde SCHEMBL28963673 | 0.68 | OXTR (0.45) | MAOBTSHRCA12CA9MAOA | |
| Chromanone SCHEMBL28794 | 0.68 | MAOB (0.56) | MAOBADORA3ARKDM4ECYP19A1 | |
| SCHEMBL8309834 | 0.68 | MAOB (0.40) | MAOBADORA3ARKDM4ECYP19A1 | |
| 3-Coumaranone SCHEMBL69412 | 0.67 | PKM (0.56) | MAOBADORA3ARKDM4ECYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300665-B1 | Cephalosporin compounds, process for their preparation and their pharmaceutical compositions | ZENECA PHARMA SA (FR) | 1995-12-20 | — | — | EP | claimed |
| EP-0304155-B1 | Cephalosporin compounds, process for their preparation and their pharmaceutical compositions | ZENECA PHARMA SA (FR) | 1995-11-15 | — | — | EP | claimed |
| EP-0225182-B1 | CEPHALOSPORIN COMPOUNDS | ICI PHARMA (FR) | 1993-02-10 | — | — | EP | claimed |
| US-5013731-A | Bactericides | ICI PHARMA (FR) | 1991-05-07 | — | — | US | claimed |
| US-5008258-A | Antibiotics | I.C.I.-PHARMA (FR) | 1991-04-16 | — | — | US | claimed |
| EP-0164944-B1 | CEPHALOSPORIN DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-07-11 | — | — | EP | claimed |
| EP-0225182-A2 | Cephalosporin compounds | ICI PHARMA (FR) | 1987-06-10 | — | — | EP | claimed |
| EP-0164944-A1 | Cephalosporin derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-12-18 | — | — | EP | claimed |
| CN-101031565-B | Substituted 2H-1, 3-benzoxazin-4 (3H) -ones | PORTOLA PHARM INC | 2010-09-29 | — | — | CN | disclosed |
| CN-101031565-A | Substituted 2H-1, 3-benzoxazin-4 (3H) -ones | PORTOLA PHARM INC (US) | 2007-09-05 | — | — | CN | disclosed |
| EP-1812429-A2 | SUBSTITUTED 2H-1,3-BENZOXAZIN-4(3H)-ONES | Portola Pharmaceuticals, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| US-7205296-B2 | Substituted 2H-1,3-benzoxazin-4(3H)-ones | PORTOLA PHARMACEUTICALS, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2006039212-A3 | SUBSTITUTED 2H-1,3-BENZOXAZIN-4(3H)-ONES | PORTOLA PHARM INC (US) | 2007-01-25 | — | — | WO | disclosed |
| WO-2006039212-A2 | SUBSTITUTED 2H-1,3-BENZOXAZIN-4(3H)-ONES | PORTOLA PHARMACEUTICALS, INC. (US) | 2006-04-13 | — | — | WO | disclosed |
| US-5008258-A | Antibiotics | I.C.I.-PHARMA (FR) | 1991-04-16 | — | — | US | disclosed |
| EP-0164944-B1 | CEPHALOSPORIN DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-07-11 | — | — | EP | disclosed |
| EP-0304155-A2 | Cephalosporin compounds, process for their preparation and their pharmaceutical compositions | ZENECA Pharma S.A. (FR) | 1989-02-22 | — | — | EP | disclosed |
| EP-0225182-A2 | Cephalosporin compounds | ICI PHARMA (FR) | 1987-06-10 | — | — | EP | disclosed |
| EP-0224385-A2 | Intermediates for the preparation of beta-lactam antibiotics | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-06-03 | — | — | EP | disclosed |
| EP-0164944-A1 | Cephalosporin derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-12-18 | — | — | EP | disclosed |