Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | DBH | P09172 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TAF1 | P21675 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14515066 | 0.80 | DHPS (0.46) | DHPSEGLN1ALDH1A1DBHMAPK14 | |
| SCHEMBL6385918 | 0.76 | MEN1 (0.46) | DHPSEGLN1ALDH1A1DBHMAPK14 | |
| SCHEMBL1757848 | 0.71 | ACHE (0.59) | DHPSEGLN1ALDH1A1MAPK14LMNA | |
| SCHEMBL24499451 | 0.71 | HTR6 (0.54) | DHPSEGLN1ALDH1A1MAPK14LMNA | |
| SCHEMBL29809414 | 0.71 | ACHE (0.59) | DHPSEGLN1ALDH1A1MAPK14LMNA | |
| SCHEMBL5314553 | 0.71 | DHPS (0.44) | DHPSEGLN1ALDH1A1MAPK14LMNA | |
| SCHEMBL4147543 | 0.71 | PARP1 (0.62) | DHPSEGLN1ALDH1A1MAPK14LMNA | |
| SCHEMBL31006516 | 0.70 | HSP90AB1 (0.57) | DHPSEGLN1ALDH1A1MAPK14KDM4E | |
| SCHEMBL29283795 | 0.70 | HSP90AB1 (0.57) | DHPSEGLN1ALDH1A1MAPK14KDM4E | |
| SCHEMBL4565730 | 0.70 | DHPS (0.48) | DHPSEGLN1ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053353-A2 | PYRROLO[2,3-F] AND [3,2-F]ISOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007053353-A2 | PYRROLO[2,3-F] AND [3,2-F]ISOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070099912-A1 | Pyrrolo[2,3-F] and [3,2-F]Isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-05-03 | — | — | US | disclosed |
| US-20070099912-A1 | Pyrrolo[2,3-F] and [3,2-F]Isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-05-03 | — | — | US | disclosed |
| US-20070099912-A1 | Pyrrolo[2,3-F] and [3,2-F]Isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099912-A1 | Pyrrolo[2,3-F] and [3,2-F]Isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands | HTR2C, HTR5A, HTR6 | DHPS 1073/4885EGLN1 2592/4885ALDH1A1 1743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.