Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 5/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2090300 | 0.86 | GPBAR1 (0.42) | GPBAR1CYSLTR1ACACBMTNR1AMTNR1B | |
| SCHEMBL5273491 | 0.86 | MCHR1 (0.36) | MTNR1AMTNR1BMCHR1LTA4H | |
| SCHEMBL7337414 | 0.83 | PLAU (0.33) | ACACBMCHR1LTA4H | |
| SCHEMBL27428113 | 0.82 | LTA4H (0.48) | MAPTACACBLTA4H | |
| SCHEMBL128132 | 0.80 | ALDH1A3 (0.41) | GAAALDH1A1 | |
| SCHEMBL17133997 | 0.80 | — | — | |
| SCHEMBL3163544 | 0.77 | BCHE (0.31) | — | |
| SCHEMBL11176381 | 0.77 | — | — | |
| SCHEMBL122883 | 0.77 | ACACB (0.45) | GPBAR1CYSLTR1MAPTACACBMTNR1A | |
| SCHEMBL3227609 | 0.77 | LMNA (0.34) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106232120-B | Process for preparing N-benzyl-3-hydroxy-4-substituted-pyridin-2- (1H) -ones | 爱尔皮奥治疗有限公司 | 2021-01-08 | — | — | CN | claimed |
| CN-106554325-B | A kind of preparation method of chirality benzene sulfinyl aminated compounds | 上海交通大学 | 2019-02-22 | — | — | CN | claimed |
| CN-106554325-A | A kind of preparation method of chiral benzene sulfinyl aminated compounds | 上海交通大学 | 2017-04-05 | — | — | CN | claimed |
| EP-3107542-A1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | Aerpio Therapeutics, Inc. (US) | 2016-12-28 | — | — | EP | claimed |
| CN-106232120-A | The method preparing N benzyl 3 hydroxyl 4 substituted pyridine 2 (1H) ketone | 爱尔皮奥治疗有限公司 | 2016-12-14 | — | — | CN | claimed |
| US-9388135-B2 | Process for preparing N-benzyl-3-hydroxy-4-substituted-pyridin-2-(1H)-ones | AERPIO THERAPEUTICS, INC. (US) | 2016-07-12 | — | — | US | claimed |
| WO-2015126860-A1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | AERPIO THERAPEUTICS, INC. (US) | 2015-08-27 | — | — | WO | claimed |
| US-20150232425-A1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | AERPIO THERAPEUTICS, INC. | 2015-08-20 | — | — | US | claimed |
| CN-104447495-A | Preparation method of chiral beta-substituted-alpha, beta-unsaturated amino alcohol compound | UNIV SHANGHAI JIAOTONG | 2015-03-25 | — | — | CN | claimed |
| CN-110573013-B | Plant disease control agent | 明治制果药业株式会社 | 2021-10-29 | — | — | CN | disclosed |
| US-20210120817-A1 | PLANT DISEASE CONTROL AGENT | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2021-04-29 | — | — | US | disclosed |
| CN-110573013-A | Plant disease control agent | 明治制果药业株式会社 | 2019-12-13 | — | — | CN | disclosed |
| EP-3107542-B1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | AERPIO THERAPEUTICS INC (US) | 2019-05-01 | — | — | EP | disclosed |
| CN-106554325-B | A kind of preparation method of chirality benzene sulfinyl aminated compounds | 上海交通大学 | 2019-02-22 | — | — | CN | disclosed |
| EP-0248084-A4 | MODULATION OF ANIMAL CELLULAR RESPONSES WITH COMPOSITIONS CONTAINING ISOXANTHOPTERIN-8-(1'-BETA-ALDOGLYCOSIDYL) DERIVATIVES. | SCRIPPS CLINIC RES (US) | 1988-03-30 | — | — | EP | disclosed |
| EP-0248084-A1 | MODULATION OF ANIMAL CELLULAR RESPONSES WITH COMPOSITIONS CONTAINING ISOXANTHOPTERIN-8-(1'-BETA-ALDOGLYCOSIDYL) DERIVATIVES. | SCRIPPS CLINIC RES (US) | 1987-12-09 | — | — | EP | disclosed |
| WO-1987003617-A1 | MODULATION OF ANIMAL CELLULAR RESPONSES WITH COMPOSITIONS CONTAINING ISOXANTHOPTERIN-8-(1'-BETA-ALDOGLYCOSIDYL) DERIVATIVES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1987-06-18 | — | — | WO | disclosed |
| US-4120886-A | APHIDICIDES | PPG INDUSTRIES, INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-4075006-A | PESTICIDES, NEMATOCIDES, FUNGICIDES | PPG INDUSTRIES, INC. (US) | 1978-02-21 | — | — | US | disclosed |
| US-4055656-A | S-ARYL-N-CYCLOALKYLTHIOLCARBAMATES | PPG INDUSTRIES, INC. (US) | 1977-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232425-A1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | CYP4B1, CYP8B1, HPD | GPBAR1 4016/4885CYSLTR1 3583/4885MAPT 3400/4885 |
| US-20210120817-A1 | PLANT DISEASE CONTROL AGENT | BROX, ALG1, CTRL | GPBAR1 2399/4885CYSLTR1 2666/4885MAPT 1126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.