Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102331 | 0.71 | PDPK1 (0.59) | PDPK1LOXL2CYP2A6HSP90AA1ADORA2A | |
| SCHEMBL3596326 | 0.70 | CYP2A6 (0.35) | CYP2A6ADRB2RAB9ANOS1 | |
| SCHEMBL28154527 | 0.69 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6HSP90AA1ADORA2A | |
| SCHEMBL30534095 | 0.69 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6HSP90AA1ADORA2A | |
| SCHEMBL31556353 | 0.69 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6HSP90AA1ADORA2A | |
| SCHEMBL30632310 | 0.69 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6HSP90AA1ADORA2A | |
| SCHEMBL6206 | 0.68 | PDPK1 (0.63) | PDPK1LOXL2CYP2A6HSP90AA1ADORA2A | |
| SCHEMBL2407299 | 0.68 | PDPK1 (0.42) | PDPK1LOXL2CYP2A6HSP90AA1ADORA2A | |
| SCHEMBL722198 | 0.67 | PDPK1 (0.77) | PDPK1LOXL2CYP2A6HSP90AA1ADORA2A | |
| SCHEMBL4648 | 0.67 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6HSP90AA1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2487180-B1 | NOVEL ARTIFICIAL FLUORESCENT BASES | RIKEN (JP) | 2014-12-03 | — | — | EP | claimed |
| US-8895712-B2 | Artificial base pair capable of forming specific base pair | RIKEN (JP) | 2014-11-25 | — | — | US | claimed |
| US-8637531-B2 | Pyrido(3,2-d)pyridmidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2014-01-28 | — | — | US | claimed |
| US-20120245340-A1 | NOVEL ARTIFICIAL FLUORESCENT BASES | TAGCYX BIOTECHNOLOGIES (JP) | 2012-09-27 | — | — | US | claimed |
| US-20120231462-A1 | ARTIFICIAL BASE PAIR CAPABLE OF FORMING SPECIFIC BASE PAIR | TAGCYX BIOTECHNOLOGIES (JP) | 2012-09-13 | — | — | US | claimed |
| EP-2487180-A1 | NOVEL ARTIFICIAL FLUORESCENT BASES | Riken (JP) | 2012-08-15 | — | — | EP | claimed |
| EP-2487181-A1 | ARTIFICIAL BASE PAIR CAPABLE OF FORMING SPECIFIC BASE PAIR | Riken (JP) | 2012-08-15 | — | — | EP | claimed |
| US-20100048559-A1 | PYRIDO(3,2-d)PYRIDMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | Gilead Science, Inc (US) | 2010-02-25 | — | — | US | claimed |
| WO-2008077650-A1 | PYRIDO(3,2-D)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-03 | — | — | WO | claimed |
| CN-1829721-A | Spiro '1-azabicyclo' 2.2.2! octan-3,5'-oxazolidin - 2'-one! derivatives with affinity to the alpha7 nicotinic acetylcholine receptor | ASTRAZENECA AB (SE) | 2006-09-06 | — | — | CN | claimed |
| US-9285319-B2 | Nucleic acid base analogs with quenching and fluorescent activities and applications thereof | RIKEN (JP) | 2016-03-15 | — | — | US | disclosed |
| EP-2415763-B1 | PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING GLAUCOMA | UBE INDUSTRIES (JP) | 2016-01-27 | — | — | EP | disclosed |
| EP-2487180-B1 | NOVEL ARTIFICIAL FLUORESCENT BASES | RIKEN (JP) | 2014-12-03 | — | — | EP | disclosed |
| US-8895712-B2 | Artificial base pair capable of forming specific base pair | RIKEN (JP) | 2014-11-25 | — | — | US | disclosed |
| US-20140113907-A1 | PYRIDYLAMINOACETIC ACID COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2014-04-24 | — | — | US | disclosed |
| WO-2007118900-A1 | HETEROCYCLIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5HT6 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007118899-A1 | HETEROCYCLIC ARYLSULPHONES SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5HT6 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2007-10-25 | — | — | WO | disclosed |
| CN-1829721-A | Spiro '1-azabicyclo' 2.2.2! octan-3,5'-oxazolidin - 2'-one! derivatives with affinity to the alpha7 nicotinic acetylcholine receptor | ASTRAZENECA AB (SE) | 2006-09-06 | — | — | CN | disclosed |
| CN-1240707-C | 2-Halo-6-0-substituted ketolide derivatives | ABBOTT LAB (US) | 2006-02-08 | — | — | CN | disclosed |
| CN-1283199-A | 2-Halo-6-0-substituted ketolide derivatives | ABBOTT LAB (US) | 2001-02-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120231462-A1 | ARTIFICIAL BASE PAIR CAPABLE OF FORMING SPECIFIC BASE PAIR | NSUN2, EIF2AK2, NSUN3 | PDPK1 4615/4885LOXL2 2936/4885CYP2A6 3732/4885 |
| US-20120245340-A1 | NOVEL ARTIFICIAL FLUORESCENT BASES | NUDT1, NT5C3B, NSUN2 | PDPK1 4122/4885LOXL2 4768/4885CYP2A6 3350/4885 |
| US-20140113907-A1 | PYRIDYLAMINOACETIC ACID COMPOUND | PTGER2, PTGER1, PTGDR2 | PDPK1 2833/4885LOXL2 395/4885CYP2A6 215/4885 |
| US-20100048559-A1 | PYRIDO(3,2-d)PYRIDMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | PNPO, PLPBP, PDXK | PDPK1 3670/4885LOXL2 2370/4885CYP2A6 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.