Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5420145 | 0.78 | MKNK1 (0.38) | CHEK2ALDH1A1MKNK1MKNK2IP6K1 | |
| SCHEMBL7680894 | 0.73 | BCAT2 (0.50) | BCAT2DHODH | |
| SCHEMBL7680902 | 0.73 | BCAT2 (0.40) | AURKABCAT2DHODH | |
| SCHEMBL7673605 | 0.71 | PARP10 (0.37) | ALDH1A1MKNK1MKNK2BCAT2 | |
| SCHEMBL30556675 | 0.71 | HTR6 (0.58) | ALDH1A1PRKD2 | |
| SCHEMBL2026663 | 0.70 | L3MBTL1 (0.52) | CHEK2MKNK1MKNK2IP6K1JAK3 | |
| SCHEMBL30903715 | 0.70 | L3MBTL1 (0.52) | CHEK2MKNK1MKNK2IP6K1JAK3 | |
| SCHEMBL28218967 | 0.70 | PTGS1 (0.51) | CHEK2ALDH1A1MKNK1MKNK2BCAT2 | |
| Hydrochloric Acid SCHEMBL28812686 | 0.69 | CHEK2 (0.50) | CHEK2MKNK1MKNK2IP6K1JAK3 | |
| SCHEMBL3781170 | 0.68 | MKNK1 (0.53) | CHEK2ALDH1A1MKNK1MKNK2IP6K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077457-A9 | TREATMENT OF EQUINE LAMINITIS WITH 5-HT1B/ 1D ANTAGONISTS | ROYAL VETERINARY COLLEGE (GB) | 2007-10-18 | — | — | WO | claimed |
| WO-2007077457-A2 | TREATMENT OF EQUINE LAMINITIS WITH 5-HT1B/ 1D ANTAGONISTS | THE ROYAL VETERINARY COLLEGE (GB) | 2007-07-12 | — | — | WO | claimed |
| WO-2007077457-A9 | TREATMENT OF EQUINE LAMINITIS WITH 5-HT1B/ 1D ANTAGONISTS | ROYAL VETERINARY COLLEGE (GB) | 2007-10-18 | — | — | WO | disclosed |