Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5335642 | 0.78 | CHEK2 (0.40) | MKNK1MKNK2ALDH1A1CHEK2IP6K1 | |
| SCHEMBL2026285 | 0.71 | ESR2 (0.55) | MKNK1MKNK2ALDH1A1HPGDCHEK2 | |
| SCHEMBL30556675 | 0.69 | HTR6 (0.58) | ALDH1A1PRKD2 | |
| SCHEMBL2026663 | 0.69 | L3MBTL1 (0.52) | MKNK1MKNK2CHEK2IP6K1JAK3 | |
| SCHEMBL30903715 | 0.69 | L3MBTL1 (0.52) | MKNK1MKNK2CHEK2IP6K1JAK3 | |
| SCHEMBL29854461 | 0.68 | MAPK14 (0.51) | MKNK1MKNK2ALDH1A1HPGDCHEK2 | |
| Hydrochloric Acid SCHEMBL28812686 | 0.67 | CHEK2 (0.50) | MKNK1MKNK2CHEK2IP6K1JAK3 | |
| SCHEMBL3781170 | 0.66 | MKNK1 (0.53) | MKNK1MKNK2ALDH1A1CHEK2IP6K1 | |
| SCHEMBL944091 | 0.66 | BCAT2 (0.63) | MKNK1MKNK2CHEK2IP6K1BRD4 | |
| SCHEMBL4530801 | 0.66 | MKNK1 (0.46) | MKNK1MKNK2HPGDCHEK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077457-A9 | TREATMENT OF EQUINE LAMINITIS WITH 5-HT1B/ 1D ANTAGONISTS | ROYAL VETERINARY COLLEGE (GB) | 2007-10-18 | — | — | WO | claimed |
| WO-2007077457-A2 | TREATMENT OF EQUINE LAMINITIS WITH 5-HT1B/ 1D ANTAGONISTS | THE ROYAL VETERINARY COLLEGE (GB) | 2007-07-12 | — | — | WO | claimed |