Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1145863 | 0.89 | MAOA (0.52) | CA2MAOAMAOB | |
| SCHEMBL12040614 | 0.87 | SIGMAR1 (0.53) | MAPTRXFP1MAOAMAOB | |
| SCHEMBL31500399 | 0.87 | SIGMAR1 (0.53) | MAPTRXFP1MAOAMAOB | |
| SCHEMBL12040636 | 0.87 | SIGMAR1 (0.53) | MAPTRXFP1MAOAMAOB | |
| SCHEMBL687602 | 0.82 | CA2 (0.53) | NOS1ADRA1ASLC6A3CA2MAOA | |
| Carbamic Acid SCHEMBL5341970 | 0.77 | MAPT (0.57) | LMNAMAPTRXFP1HDAC1HDAC2 | |
| Carbamic Acid SCHEMBL2222080 | 0.76 | FFAR1 (0.62) | NOS1LMNAMAPTRXFP1HDAC1 | |
| SCHEMBL273440 | 0.76 | ALDH1A1 (0.50) | NOS1SMN1; SMN2CA2MAOAMAOB | |
| Hydrocinnamyl Alcohol SCHEMBL27682093 | 0.75 | LMNA (0.58) | NOS1LMNAMAPTRXFP1HDAC1 | |
| SCHEMBL1285919 | 0.75 | MAPT (0.70) | LMNAMAPTRXFP1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756068-A1 | BENZIMIDAZOLES, METHOD FOR PRODUCING THEM AND THE USE THEREOF AS DRUGS | Boehringer Ingelheim International GmbH (DE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005121103-A1 | BENZIMIDAZOLES, METHOD FOR PRODUCING THEM AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-22 | — | — | WO | disclosed |