Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 6/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316855 | 0.88 | VCP (0.62) | IMPDH2KDRNPC1RAB9AROCK2 | |
| SCHEMBL5344457 | 0.86 | IGF1R (0.50) | IMPDH2KDRSYKNPC1RAB9A | |
| SCHEMBL5318416 | 0.85 | TNIK (0.60) | IMPDH2KDRSYKTNIKNPC1 | |
| SCHEMBL5348009 | 0.83 | RET (0.49) | IMPDH2KDRSYKTNIKROCK2 | |
| SCHEMBL5338142 | 0.82 | VCP (0.65) | IMPDH2KDRSYKTNIKNPC1 | |
| SCHEMBL5319904 | 0.81 | FLT1 (0.57) | IMPDH2KDRNPC1RAB9ARET | |
| SCHEMBL5344443 | 0.81 | KDR (0.59) | IMPDH2KDRSYKTNIKRET | |
| SCHEMBL5433991 | 0.79 | RAF1 (0.52) | IMPDH2KDRTNIKRETVCP | |
| SCHEMBL5338278 | 0.79 | KDR (0.51) | IMPDH2KDRSYKTNIKROCK2 | |
| SCHEMBL5337093 | 0.78 | ROCK2 (0.49) | IMPDH2KDRSYKTNIKNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |