Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.65 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 7/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.54 |
| ▸ | FLT1 | P17948 | 4/20 | 0.53 |
| ▸ | FLT4 | P35916 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318416 | 0.88 | TNIK (0.60) | VCPIMPDH2KDRROCK2ROCK1 | |
| SCHEMBL14465941 | 0.84 | IMPDH2 (0.61) | VCPIMPDH2PIK3CAKDRROCK1 | |
| SCHEMBL5344443 | 0.84 | KDR (0.59) | VCPIMPDH2KDRFLT1FLT4 | |
| SCHEMBL5337614 | 0.84 | PIK3CA (0.54) | VCPIMPDH2PIK3CAKDRROCK2 | |
| SCHEMBL5317045 | 0.84 | VCP (0.63) | VCPIMPDH2PIK3CAKDRROCK2 | |
| SCHEMBL5319685 | 0.83 | IMPDH2 (0.54) | VCPIMPDH2PIK3CAKDRROCK2 | |
| SCHEMBL5337102 | 0.82 | IMPDH2 (0.54) | VCPIMPDH2KDRROCK2ROCK1 | |
| SCHEMBL5336680 | 0.82 | IMPDH2 (0.59) | VCPIMPDH2PIK3CAKDRROCK1 | |
| SCHEMBL5319904 | 0.82 | FLT1 (0.57) | IMPDH2KDRFLT1FLT4NPC1 | |
| SCHEMBL5433991 | 0.82 | RAF1 (0.52) | VCPIMPDH2KDRFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |