Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.69 |
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | CASP1 | P29466 | 1/20 | 0.69 |
| ▸ | CASP7 | P55210 | 1/20 | 0.69 |
| ▸ | CA9 | Q16790 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 5/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | PPARG | P37231 | 1/20 | 0.63 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.63 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | PON1 | P27169 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12457526 | 0.93 | ALDH1A1 (0.74) | ALDH1A1TSHRHPGDCYP3A4HSD17B10 | |
| SCHEMBL5118377 | 0.85 | ALDH1A1 (0.86) | ALDH1A1TSHRHPGDCYP3A4HSD17B10 | |
| 4,5,7-Trimethyl-2H-Chromen-2-One SCHEMBL18096558 | 0.84 | KDM4E (0.66) | ALDH1A1TSHRHPGDCYP3A4HSD17B10 | |
| 5,7-Dihydroxy-4-Methylcoumarin SCHEMBL29431030 | 0.81 | ALDH1A1 (1.00) | ALDH1A1TSHRHPGDCYP3A4HSD17B10 | |
| 5,7-Dihydroxy-4-Methylcoumarin SCHEMBL403833 | 0.81 | ALDH1A1 (1.00) | ALDH1A1TSHRHPGDCYP3A4HSD17B10 | |
| 5,7-Dihydroxy-4-Methylcoumarin SCHEMBL4395631 | 0.80 | ALDH1A1 (0.96) | ALDH1A1TSHRHPGDCYP3A4HSD17B10 | |
| SCHEMBL5346812 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TSHRHPGDCYP3A4HSD17B10 | |
| SCHEMBL11851931 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TSHRHPGDCYP3A4HSD17B10 | |
| SCHEMBL5312532 | 0.77 | ALDH1A1 (1.00) | ALDH1A1TSHRHPGDCYP3A4HSD17B10 | |
| SCHEMBL12525172 | 0.76 | ALDH1A1 (0.78) | ALDH1A1TSHRHPGDCYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107382944-B | Coumarin gossypol derivatives with anti-tumor activity and synthesis method thereof | 陕西盘龙医药股份有限公司 | 2020-05-29 | — | — | CN | disclosed |
| CN-107382944-A | One kind has the cumarin gossypol derivative and its synthetic method of antitumor activity | 陕西科技大学 | 2017-11-24 | — | — | CN | disclosed |
| US-9758503-B1 | Coumarin-gossypol derivatives with antitumor activities and a method of preparing the same | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-09-12 | — | — | US | disclosed |
| US-9758503-B1 | Coumarin-gossypol derivatives with antitumor activities and a method of preparing the same | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-09-12 | — | — | US | disclosed |
| US-9758503-B1 | Coumarin-gossypol derivatives with antitumor activities and a method of preparing the same | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-09-12 | — | — | US | disclosed |
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2008-06-26 | — | — | US | disclosed |
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2008-06-26 | — | — | US | disclosed |
| US-7208518-B2 | Substituted furochromene compounds of antiinflammatory action | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2007-04-24 | — | — | US | disclosed |
| US-20060148890-A1 | Substituted furochromene compounds of antiinflammatory action | PLIVA-LSTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-07-06 | — | — | US | disclosed |
| EP-1648901-A1 | SUBSTITUTED FUROCHROMENE COMPOUNDS OF ANTIINFLAMMATORY ACTION | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005010006-A1 | SUBSTITUTED FUROCHROMENE COMPOUNDS OF ANTIINFLAMMATORY ACTION | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-02-03 | — | — | WO | disclosed |
| US-4288450-A | ANTIALLERGENS | CIBA-GEIGY CORPORATION (US) | 1981-09-08 | — | — | US | disclosed |
| US-4216155-A | 3-GLYCOLOYLAMINO-4-OXO-4H-1-BENZOPYRAN; ANTIALLERGENS | CIBA-GEIGY CORPORATION (US) | 1980-08-05 | — | — | US | disclosed |
| EP-0000488-A1 | 3-Oxaloamino-4-oxo-4H-1-benzopyrane compounds, process for their preparation and their pharmaceutical use | CIBA-GEIGY AG (CH) | 1979-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | NOD1, NOD2, CASP1 | ALDH1A1 2298/4885TSHR 4610/4885HPGD 522/4885 |
| US-20060148890-A1 | Substituted furochromene compounds of antiinflammatory action | LTC4S, CYP11B2, CYP11B1 | ALDH1A1 550/4885TSHR 4131/4885HPGD 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.