Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 5/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | FLT1 | P17948 | 4/20 | 0.45 |
| ▸ | FLT4 | P35916 | 4/20 | 0.45 |
| ▸ | CDC7 | O00311 | 2/20 | 0.45 |
| ▸ | VCP | P55072 | 2/20 | 0.43 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318247 | 0.91 | IMPDH2 (0.57) | IMPDH2FGFR1PIM1PIM3PIM2 | |
| SCHEMBL14465936 | 0.88 | IMPDH2 (0.61) | IMPDH2FGFR1KDRFLT1FLT4 | |
| SCHEMBL5345370 | 0.83 | VCP (0.63) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL5333251 | 0.81 | IMPDH2 (0.55) | IMPDH2KDRFLT1FLT4CDC7 | |
| SCHEMBL5339016 | 0.81 | VCP (0.58) | IMPDH2FGFR1KDRFLT1FLT4 | |
| SCHEMBL14465934 | 0.81 | IMPDH2 (0.46) | IMPDH2FGFR1PIM1PIM3PIM2 | |
| SCHEMBL14465941 | 0.79 | IMPDH2 (0.61) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL5342641 | 0.79 | TRPV1 (0.61) | IMPDH2KITKDRFLT1FLT4 | |
| SCHEMBL5316737 | 0.79 | IMPDH2 (0.55) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL5316813 | 0.77 | MAPT (0.54) | IMPDH2KDRFLT1FLT4CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |