Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | FLT1 | P17948 | 3/20 | 0.45 |
| ▸ | FLT4 | P35916 | 3/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5338255 | 0.91 | IMPDH2 (0.57) | IMPDH2PIM1PIM3PIM2FGFR1 | |
| SCHEMBL14465941 | 0.88 | IMPDH2 (0.61) | IMPDH2ROCK1KDRFLT1FLT4 | |
| SCHEMBL5336680 | 0.86 | IMPDH2 (0.59) | IMPDH2ROCK1KDRFLT1FLT4 | |
| SCHEMBL5337614 | 0.83 | PIK3CA (0.54) | IMPDH2ROCK2ROCK1KDRFLT1 | |
| SCHEMBL5317045 | 0.83 | VCP (0.63) | IMPDH2ROCK2ROCK1KDRFLT1 | |
| SCHEMBL5319685 | 0.82 | IMPDH2 (0.54) | IMPDH2ROCK2ROCK1MAPKAPK2FGFR1 | |
| SCHEMBL5335613 | 0.81 | CDC7 (0.58) | IMPDH2ROCK2ROCK1MAPKAPK2KDR | |
| SCHEMBL5336433 | 0.81 | MKNK1 (0.51) | IMPDH2ROCK2ROCK1MAPKAPK2KDR | |
| SCHEMBL5333205 | 0.81 | IMPDH2 (0.53) | IMPDH2ROCK2ROCK1MAPKAPK2KDR | |
| SCHEMBL5316809 | 0.81 | NOS1 (0.48) | IMPDH2ROCK2ROCK1MAPKAPK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |