Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 3/20 | 0.46 |
| ▸ | FLT4 | P35916 | 3/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317045 | 0.91 | VCP (0.63) | VCPSIRT7IMPDH2KDRFLT1 | |
| SCHEMBL5339016 | 0.87 | VCP (0.58) | VCPMAPTHTTALDH1A1THRB | |
| SCHEMBL14465936 | 0.87 | IMPDH2 (0.61) | VCPMAPTIMPDH2KDRFLT1 | |
| SCHEMBL5338255 | 0.83 | IMPDH2 (0.57) | VCPIMPDH2KDRFLT1FLT4 | |
| SCHEMBL5316813 | 0.81 | MAPT (0.54) | MAPTHTTALDH1A1THRBIMPDH2 | |
| SCHEMBL5333251 | 0.81 | IMPDH2 (0.55) | VCPMAPTHTTALDH1A1SIRT7 | |
| SCHEMBL5334372 | 0.78 | KDR (0.59) | VCPMAPTHTTALDH1A1IMPDH2 | |
| SCHEMBL5343891 | 0.78 | VCP (0.58) | VCPSIRT7IMPDH2KDRFLT1 | |
| SCHEMBL14465941 | 0.78 | IMPDH2 (0.61) | VCPIMPDH2KDRFLT1FLT4 | |
| SCHEMBL5337614 | 0.78 | PIK3CA (0.54) | VCPIMPDH2KDRFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |