Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | FLT1 | P17948 | 4/20 | 0.53 |
| ▸ | FLT4 | P35916 | 4/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | VCP | P55072 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318416 | 0.91 | TNIK (0.60) | IMPDH2KDRFLT1FLT4TNIK | |
| SCHEMBL5333251 | 0.87 | IMPDH2 (0.55) | IMPDH2KDM4EALDH1A1MAPTKDR | |
| SCHEMBL5334372 | 0.87 | KDR (0.59) | IMPDH2KDM4EALDH1A1MAPTKDR | |
| SCHEMBL5339016 | 0.85 | VCP (0.58) | IMPDH2KDM4EALDH1A1MAPTKDR | |
| SCHEMBL14465936 | 0.85 | IMPDH2 (0.61) | IMPDH2KDM4EMAPTKDRFLT1 | |
| SCHEMBL5342641 | 0.82 | TRPV1 (0.61) | IMPDH2KDRFLT1FLT4 | |
| SCHEMBL5339083 | 0.82 | VCP (0.63) | IMPDH2ALDH1A1MAPTKDRFLT1 | |
| SCHEMBL5338142 | 0.80 | VCP (0.65) | IMPDH2KDRFLT1FLT4TNIK | |
| SCHEMBL5338255 | 0.79 | IMPDH2 (0.57) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL5344443 | 0.78 | KDR (0.59) | IMPDH2KDRFLT1FLT4TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |