Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 2/20 | 0.58 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5343891 | 0.91 | VCP (0.58) | VCPSIRT7DYRK1AMAP4K4CLK2 | |
| SCHEMBL5333251 | 0.88 | IMPDH2 (0.55) | VCPSIRT7MAPTKDM4EALDH1A1 | |
| SCHEMBL14465936 | 0.88 | IMPDH2 (0.61) | VCPMAPTKDM4EGAAIMPDH2 | |
| SCHEMBL5345370 | 0.87 | VCP (0.63) | VCPSIRT7KMT2AMAPTKDM4E | |
| SCHEMBL5342641 | 0.85 | TRPV1 (0.61) | IMPDH2EIF2AK2KDRFLT1FLT4 | |
| SCHEMBL5316737 | 0.85 | IMPDH2 (0.55) | VCPMAPTKDM4EALDH1A1IMPDH2 | |
| SCHEMBL5338645 | 0.83 | VCP (0.58) | VCPSIRT7IMPDH2KDRFLT1 | |
| SCHEMBL5336708 | 0.83 | VCP (0.57) | VCPSIRT7IMPDH2KDRFLT1 | |
| SCHEMBL5339083 | 0.82 | VCP (0.63) | VCPSIRT7MAPTALDH1A1IMPDH2 | |
| SCHEMBL5338255 | 0.81 | IMPDH2 (0.57) | VCPDYRK1ACLK4IMPDH2EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |