Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533935 | 0.79 | PPARG (0.41) | PPARGPPARA | |
| SCHEMBL555956 | 0.74 | PPARG (0.37) | KDM4ETDP1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL19465522 | 0.72 | PPARA (0.40) | KDM4EPOLBALDH1A1PPARA | |
| SCHEMBL12971378 | 0.68 | HDAC6 (0.38) | KDM4EL3MBTL1TDP1POLB | |
| SCHEMBL4666766 | 0.68 | TAS1R3 (0.41) | L3MBTL1LMNAMAPK1FFAR1PPARD | |
| SCHEMBL534650 | 0.67 | SMN1; SMN2 (0.51) | KDM4EL3MBTL1TDP1POLBLMNA | |
| SCHEMBL533933 | 0.67 | PPARG (0.59) | PPARGPPARDPPARA | |
| SCHEMBL555957 | 0.67 | MTNR1A (0.38) | FFAR1SMN1; SMN2CHEK2PPARG | |
| SCHEMBL21718856 | 0.66 | FBP1 (0.36) | KDM4ELMNAMAPK1ALDH1A1CHEK2 | |
| SCHEMBL8257155 | 0.66 | SLC6A4 (0.40) | KDM4ESMN1; SMN2CHEK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | KDM4E 2653/4885L3MBTL1 4282/4885TDP1 3892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.