Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316958 | 0.86 | VCP (0.52) | CYP11B1CYP11B2KIF11GABRG2GABRB3 | |
| SCHEMBL5316750 | 0.86 | KIF11 (0.48) | CYP11B1CYP11B2KIF11GABRG2GABRB3 | |
| SCHEMBL5318196 | 0.85 | KDR (0.52) | CYP11B1CYP11B2KIF11GABRG2GABRB3 | |
| SCHEMBL5338297 | 0.83 | SYK (0.54) | CYP11B1CYP11B2KIF11GABRG2GABRB3 | |
| SCHEMBL5334965 | 0.81 | VCP (0.57) | CYP11B1CYP11B2KIF11GABRG2GABRB3 | |
| SCHEMBL14465950 | 0.81 | KIF11 (0.48) | CYP11B1CYP11B2KIF11GABRG2GABRB3 | |
| SCHEMBL5319534 | 0.80 | VCP (0.52) | SYK | |
| SCHEMBL5339461 | 0.79 | KDR (0.52) | SYKROCK1FLT1KDR | |
| SCHEMBL5337884 | 0.78 | SYK (0.48) | TNIKSYKCLK1CLK2DYRK1A | |
| SCHEMBL5339243 | 0.72 | SYK (0.56) | TNIKSYKCLK2DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |