Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.52 |
| ▸ | FLT1 | P17948 | 9/20 | 0.52 |
| ▸ | FLT4 | P35916 | 9/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | VCP | P55072 | 1/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5339461 | 0.91 | KDR (0.52) | KDRFLT1FLT4ROCK1VCP | |
| SCHEMBL5316750 | 0.89 | KIF11 (0.48) | ROCK1KIF11CYP11B1CYP11B2GABRG2 | |
| SCHEMBL5316958 | 0.89 | VCP (0.52) | KDRFLT1FLT4ROCK1KIF11 | |
| SCHEMBL5341998 | 0.85 | PKM (0.47) | KDRFLT1ROCK1KIF11CYP11B1 | |
| SCHEMBL14465950 | 0.84 | KIF11 (0.48) | KDRROCK1KIF11IMPDH2CYP11B1 | |
| SCHEMBL5334965 | 0.84 | VCP (0.57) | KDRFLT1FLT4ROCK1KIF11 | |
| SCHEMBL5338297 | 0.83 | SYK (0.54) | KDRFLT1FLT4KIF11VCP | |
| SCHEMBL5318114 | 0.82 | KDR (0.54) | KDRFLT1FLT4ROCK1KIF11 | |
| SCHEMBL5342093 | 0.82 | ACLY (0.46) | KDRFLT1FLT4ROCK1VCP | |
| SCHEMBL5319534 | 0.81 | VCP (0.52) | VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |