Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.52 |
| ▸ | FLT1 | P17948 | 8/20 | 0.52 |
| ▸ | FLT4 | P35916 | 8/20 | 0.52 |
| ▸ | VCP | P55072 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318196 | 0.91 | KDR (0.52) | KDRFLT1FLT4VCPIMPDH2 | |
| SCHEMBL5319534 | 0.89 | VCP (0.52) | VCPKMT2APARP1SYKALDH1A1 | |
| SCHEMBL5342093 | 0.82 | ACLY (0.46) | KDRFLT1FLT4VCPIMPDH2 | |
| SCHEMBL5316750 | 0.81 | KIF11 (0.48) | ROCK1SYK | |
| SCHEMBL5316958 | 0.81 | VCP (0.52) | KDRFLT1FLT4VCPIMPDH2 | |
| SCHEMBL5318114 | 0.80 | KDR (0.54) | KDRFLT1FLT4VCPIMPDH2 | |
| SCHEMBL5341998 | 0.79 | PKM (0.47) | KDRFLT1ROCK1SYK | |
| SCHEMBL14465950 | 0.76 | KIF11 (0.48) | KDRKMT2AIMPDH2ROCK1SYK | |
| SCHEMBL5334965 | 0.76 | VCP (0.57) | KDRFLT1FLT4VCPROCK1 | |
| SCHEMBL5338297 | 0.75 | SYK (0.54) | KDRFLT1FLT4VCPKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |