Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | EDNRB | P24530 | 2/20 | 0.53 |
| ▸ | EDNRA | P25101 | 2/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CCR4 | P51679 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PKLR | P30613 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5343634 | 0.86 | EDNRB (0.53) | SLC40A1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5343689 | 0.84 | HSD11B1 (0.60) | SLC40A1ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL5344543 | 0.84 | HSD11B1 (0.50) | SLC40A1ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL6984890 | 0.83 | ALDH1A1 (0.67) | SLC40A1ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL5338606 | 0.81 | HSD11B1 (0.55) | SLC40A1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5377995 | 0.81 | ALPL (0.72) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6981195 | 0.80 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5337572 | 0.80 | HSD11B1 (0.54) | SLC40A1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL617881 | 0.78 | LMNA (0.62) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL618169 | 0.78 | HSD11B1 (0.51) | SLC40A1ALDH1A1LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | HSD3B1, HSD3B2, HSD17B3 | SLC40A1 4120/4885ALDH1A1 378/4885LMNA 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.