Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
| ▸ | SGK1 | O00141 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981076 | 0.83 | ALDH1A1 (0.76) | ALPLALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL6980375 | 0.81 | LMNA (0.65) | ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL2055421 | 0.81 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2CYP3A4PPARGLMNA | |
| SCHEMBL5342156 | 0.81 | SLC40A1 (0.62) | ALPLALDH1A1SMN1; SMN2CYP3A4PPARG | |
| SCHEMBL5348053 | 0.80 | ALPL (0.58) | ALPLALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL6984890 | 0.77 | ALDH1A1 (0.67) | ALPLALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL6981195 | 0.77 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL6985862 | 0.76 | ALDH1A1 (0.78) | ALPLALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL359841 | 0.76 | NR4A2 (0.70) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL6314173 | 0.75 | ALDH1A1 (0.54) | ALPLALDH1A1SMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | HSD3B1, HSD3B2, HSD17B3 | ALPL 1926/4885ALDH1A1 378/4885SMN1; SMN2 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.