Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 9/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL556088 | 0.74 | REN (0.41) | FFAR2 | |
| SCHEMBL28264816 | 0.68 | PROKR1 (0.38) | PROKR1ALDH1A1 | |
| SCHEMBL4392361 | 0.67 | KMT2A (0.41) | PROKR1ALDH1A1MEN1KMT2AEPHX2 | |
| SCHEMBL4754555 | 0.66 | PROKR1 (0.48) | PROKR1OPRL1 | |
| SCHEMBL2364516 | 0.62 | GRM5 (0.44) | GRM5ALDH1A1MEN1KMT2AOPRL1 | |
| SCHEMBL19212445 | 0.62 | GRM5 (0.48) | GRM5KMT2AEPHX2OPRL1 | |
| SCHEMBL4099888 | 0.62 | RAB9A (0.57) | PROKR1GRM5ALDH1A1HSD11B1 | |
| SCHEMBL3999994 | 0.61 | SLC6A2 (0.57) | PROKR1HSD11B1 | |
| SCHEMBL3410172 | 0.61 | PROKR1 (0.38) | PROKR1ALDH1A1 | |
| Bicarbonate SCHEMBL17644401 | 0.60 | OPRL1 (0.51) | PROKR1GRM5OPRL1PTGDRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |