Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | DDO | Q99489 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3585887 | 0.89 | MET (0.53) | METCA12CA1CA9CYP3A4 | |
| SCHEMBL15842553 | 0.84 | KDM4E (0.53) | MCL1ALDH1A1HSD17B3MAPTGABRA1 | |
| SCHEMBL15842727 | 0.81 | KMT2A (0.57) | CYP3A4CYP1A2CYP2C19MCL1ALDH1A1 | |
| SCHEMBL30693881 | 0.80 | MET (0.61) | METCA12CA1CA9CYP3A4 | |
| SCHEMBL28480556 | 0.80 | MET (0.61) | METCA12CA1CA9CYP3A4 | |
| SCHEMBL10790754 | 0.80 | MCL1 (0.54) | MCL1ALDH1A1HSD17B3KMT2AMEN1 | |
| SCHEMBL2761835 | 0.79 | MET (0.56) | METCA12CA1CA9CYP3A4 | |
| SCHEMBL2761879 | 0.79 | MET (0.56) | METCA12CA1CA9CYP3A4 | |
| SCHEMBL10381209 | 0.76 | MET (0.56) | METCA12CA1CA9CYP3A4 | |
| SCHEMBL31323561 | 0.76 | MET (0.56) | METCA12CA1CA9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2008-06-26 | — | — | US | disclosed |
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2008-06-26 | — | — | US | disclosed |
| US-7208518-B2 | Substituted furochromene compounds of antiinflammatory action | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2007-04-24 | — | — | US | disclosed |
| CN-1839138-A | Substituted furochromene compounds with anti-inflammatory action | PLIVA ISTRAZIVACKI INST D O O (HR) | 2006-09-27 | — | — | CN | disclosed |
| US-20060148890-A1 | Substituted furochromene compounds of antiinflammatory action | PLIVA-LSTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-07-06 | — | — | US | disclosed |
| EP-1648901-A1 | SUBSTITUTED FUROCHROMENE COMPOUNDS OF ANTIINFLAMMATORY ACTION | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005010006-A1 | SUBSTITUTED FUROCHROMENE COMPOUNDS OF ANTIINFLAMMATORY ACTION | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | NOD1, NOD2, CASP1 | MET 4268/4885CA12 2096/4885CA1 721/4885 |
| US-20060148890-A1 | Substituted furochromene compounds of antiinflammatory action | LTC4S, CYP11B2, CYP11B1 | MET 3947/4885CA12 3303/4885CA1 1868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.