Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | CDC7 | O00311 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | VCP | P55072 | 3/20 | 0.46 |
| ▸ | FLT1 | P17948 | 4/20 | 0.46 |
| ▸ | FLT4 | P35916 | 3/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5335613 | 0.87 | CDC7 (0.58) | CDC7ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL14465941 | 0.87 | IMPDH2 (0.61) | PIK3CADYRK3CLK2ROCK1DYRK1A | |
| SCHEMBL5317045 | 0.87 | VCP (0.63) | PIK3CACDC7ROCK2ROCK1DYRK1A | |
| SCHEMBL5343138 | 0.86 | TRPV1 (0.53) | CDC7ROCK2ROCK1IMPDH2KDR | |
| SCHEMBL5336680 | 0.85 | IMPDH2 (0.59) | PIK3CADYRK3CLK2ROCK1DYRK1A | |
| SCHEMBL5338142 | 0.84 | VCP (0.65) | PIK3CAROCK2NPC1RAB9AROCK1 | |
| SCHEMBL5340970 | 0.84 | FLT1 (0.61) | PIK3CAROCK2IMPDH2KDRVCP | |
| SCHEMBL5319685 | 0.83 | IMPDH2 (0.54) | PIK3CACDC7ROCK2DYRK3RPS6KB1 | |
| SCHEMBL5318247 | 0.83 | IMPDH2 (0.57) | PIK3CACDC7ROCK2ROCK1IMPDH2 | |
| SCHEMBL5350220 | 0.83 | VCP (0.67) | PIK3CAROCK2NPC1DYRK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |