Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 4/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 3/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345370 | 0.91 | VCP (0.63) | VCPPIK3CASIRT7IMPDH2KDR | |
| SCHEMBL5343891 | 0.87 | VCP (0.58) | VCPSIRT7IMPDH2KDRFLT1 | |
| SCHEMBL14465941 | 0.87 | IMPDH2 (0.61) | VCPPIK3CAIMPDH2KDRFLT1 | |
| SCHEMBL5337614 | 0.87 | PIK3CA (0.54) | VCPPIK3CAIMPDH2KDRFLT1 | |
| SCHEMBL5340647 | 0.85 | KDR (0.54) | VCPSIRT7IMPDH2KDRFLT4 | |
| SCHEMBL5336680 | 0.85 | IMPDH2 (0.59) | VCPPIK3CAIMPDH2KDRFLT1 | |
| SCHEMBL5338142 | 0.84 | VCP (0.65) | VCPPIK3CAIMPDH2KDRFLT1 | |
| SCHEMBL5340970 | 0.84 | FLT1 (0.61) | VCPPIK3CAIMPDH2KDRFLT1 | |
| SCHEMBL5343138 | 0.84 | TRPV1 (0.53) | VCPIMPDH2KDRFLT1FLT4 | |
| SCHEMBL5319685 | 0.83 | IMPDH2 (0.54) | VCPPIK3CAIMPDH2KDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |