SCHEMBL5353986

SCHEMBL5353986

Nc1ccc2c(c1)[nH]c(=O)n2-c1ccc(Cl)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.64
KMT2A Q03164 2/20 0.64
LMNA P02545 1/20 0.64
L3MBTL1 Q9Y468 1/20 0.64
SMN1; SMN2 Q16637 3/20 0.48
ALDH1A1 P00352 2/20 0.44
HTT P42858 2/20 0.44
ATM Q13315 2/20 0.44
ALOX15 P16050 1/20 0.44
PDE10A Q9Y233 1/20 0.43
CA12 O43570 1/20 0.41
CA9 Q16790 1/20 0.41
MAT2A P31153 2/20 0.41
KDM4E B2RXH2 4/20 0.40
GAA P10253 2/20 0.40
TSHR P16473 1/20 0.40
TP53 P04637 2/20 0.40
DAO P14920 1/20 0.40
MAPT P10636 4/20 0.39
NPC1 O15118 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5718492 0.85 ALDH1A1 (0.50) MEN1KMT2ALMNAL3MBTL1SMN1; SMN2
SCHEMBL5718587 0.84 MEN1 (0.68) MEN1KMT2ALMNAL3MBTL1SMN1; SMN2
SCHEMBL5351065 0.81 ATM (0.52) MEN1KMT2ALMNAL3MBTL1SMN1; SMN2
SCHEMBL7843289 0.80 TSHR (0.45) MEN1KMT2ALMNAL3MBTL1ALDH1A1
SCHEMBL11696380 0.79 LMNA (0.50) MEN1KMT2ALMNAL3MBTL1SMN1; SMN2
SCHEMBL28738835 0.78 MEN1 (1.00) MEN1KMT2ALMNAL3MBTL1SMN1; SMN2
SCHEMBL23119669 0.78 LMNA (0.67) MEN1KMT2ALMNAL3MBTL1SMN1; SMN2
SCHEMBL11348908 0.78 LMNA (0.62) MEN1KMT2ALMNAL3MBTL1SMN1; SMN2
SCHEMBL11314421 0.77 MAPT (0.48) MEN1KMT2ALMNAL3MBTL1SMN1; SMN2
SCHEMBL11692618 0.77 MEN1 (0.50) MEN1KMT2ALMNAL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4670486-A Polymer composition pigmented with copper or nickel complexes of ligands containing a semicarbazone moiety CIBA-GEIGY CORPORATION (US) 1987-06-02 US claimed
US-7262284-B2 Method for producing disazo pigments CLARIANT PRODUKTE (DEUTSCHLAND) GMBH (DE) 2007-08-28 US disclosed
US-20060167236-A1 Method for producing disazo pigments CLARIANT GMBH (DE) 2006-07-27 US disclosed
EP-1132432-B1 Preparation process of pigments CLARIANT FINANCE BVI LTD (VG) 2006-02-08 EP disclosed
EP-1517962-A1 METHOD FOR PRODUCING DISAZO PIGMENTS Clariant GmbH (DE) 2005-03-30 EP disclosed
WO-2004000947-A1 METHOD FOR PRODUCING DISAZO PIGMENTS CLARIANT GMBH (DE) 2003-12-31 WO disclosed
US-6512115-B2 Preparing symmetrically disubstituted triphendioxazine compounds by cyclizing amino substituted benzoquinone intermediates in the presence of manganese oxide and sulfuric acid CLARIANT FINANCE (BVI) LIMITED (VI) 2003-01-28 US disclosed
US-20010031864-A1 Preparation of pigments CLARIANT FINANCE (BVI) LIMITED 2001-10-18 US disclosed
EP-1132432-A2 Preparation process of pigments Clariant Finance (BVI) Limited (VG) 2001-09-12 EP disclosed
EP-0168343-B1 METAL COMPLEXES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN DYEING HIGH-MOLECULAR ORGANIC MATERIALS CIBA-GEIGY AG (CH) 1991-05-02 EP disclosed
US-4263205-A FOR COLORING POLYMERS, LACQUERS CIBA-GEIGY CORPORATION (US) 1981-04-21 US disclosed
US-4229344-A Monazo pigments containing hydroxynaphthoylaminobenzimidazalone radical CIBA-GEIGY CORPORATION (US) 1980-10-21 US disclosed
US-4220586-A FASTNESS TO LIGHT, OVER-LACQUERING, MIGRATION, WEATHERING, AND HEAT CIBA-GEIGY CORPORATION (US) 1980-09-02 US disclosed
US-4116959-A ISOINDOLINE PIGMENTS CIBA-GEIGY CORPORATION (US) 1978-09-26 US disclosed
US-4088641-A YELLOW TO RED SHADES CIBA-GEIGY CORPORATION (US) 1978-05-09 US disclosed
US-4052410-A YELLOW, PLASTICS, LACQUERS CIBA-GEIGY CORPORATION (US) 1977-10-04 US disclosed
US-4012371-A Benzinaldazolyl-, quinolonyl-, or phenmorpholonylazo-3-cyano-4-methyl-1,2-[1',2']-benz-[4',5']-imidazolo-6-hydroxypyridine colorants CIBA-GEIGY CORPORATION (US) 1977-03-15 US disclosed
US-3979386-A YELLOW, COLORFASTNESS CIBA-GEIGY CORPORATION (US) 1976-09-07 US disclosed
US-3963694-A AZO PIGMENTS, POLYESTERS, CELLULOSE ETHERS AND ESTERS CIBA-GEIGY CORPORATION (US) 1976-06-15 US disclosed
US-3956266-A DISAZO DYES CIBA-GEIGY CORPORATION (US) 1976-05-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060167236-A1 Method for producing disazo pigments TYR, IPO4, CBR3 MEN1 2054/4885KMT2A 2138/4885LMNA 1543/4885
US-20010031864-A1 Preparation of pigments SCO2, PPOX, PRDX4 MEN1 216/4885KMT2A 1664/4885LMNA 1767/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.