SCHEMBL5357412

SCHEMBL5357412

COc1cccc(C(=O)n2cc(-c3ccc(C=O)o3)c3ccccc32)c1

nearest known ligand 0.51

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ELANE P08246 6/20 0.44
KMT2A Q03164 3/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 2/20 0.42
BCHE P06276 1/20 0.41
HPGD P15428 1/20 0.41
ACHE P22303 1/20 0.41
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40
THRB P10828 1/20 0.40
HTR6 P50406 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5349646 0.89 KMT2A (0.55) ELANEKMT2AKDM4EALDH1A1ACHE
SCHEMBL5356842 0.85 KDM4E (0.49) KMT2AL3MBTL1KDM4EALDH1A1HPGD
SCHEMBL5356625 0.84 KMT2A (0.45) ELANEKMT2AL3MBTL1BCHEHPGD
SCHEMBL8482779 0.75 HTR6 (0.54) ELANEKMT2AL3MBTL1KDM4EALDH1A1
SCHEMBL5354006 0.72 KMT2A (0.55) KMT2AKDM4EALDH1A1ACHETHRB
SCHEMBL14450976 0.70 ALDH1A1 (0.51) KMT2AL3MBTL1KDM4EALDH1A1HPGD
SCHEMBL2549273 0.68 PIK3CG (0.58) KMT2AL3MBTL1KDM4EALDH1A1HPGD
SCHEMBL5358132 0.67 DYRK1A (0.47) KMT2AL3MBTL1KDM4EALDH1A1HPGD
SCHEMBL5357533 0.67 KMT2A (0.56) ELANEKMT2AKDM4EALDH1A1BCHE
SCHEMBL7836476 0.67 L3MBTL1 (0.55) KMT2AL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7176230-B2 Synthesis of indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) as anti-platelet agents INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2007-02-13 US disclosed
US-20060106041-A1 Synthesis of indole analogs of 1-benzyl-3-(5'-hydroxymethy 1-2' -furyl) indazole (YC-1) as anti-platelet agents INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2006-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060106041-A1 Synthesis of indole analogs of 1-benzyl-3-(5'-hydroxymethy 1-2' -furyl) indazole (YC-1) as anti-platelet agents PFKP, HMOX1, TPH1 ELANE 2497/4885KMT2A 2910/4885L3MBTL1 3005/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.