Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.33 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9263485 | 0.98 | ACHE (0.39) | ACHEAGTR1LTB4R2ABCC3ABCC4 | |
| Hydrochloric Acid SCHEMBL535435 | 0.98 | ACHE (0.39) | ACHEAGTR1LTB4R2ABCC3ABCC4 | |
| SCHEMBL9409027 | 0.93 | ACHE (0.33) | ACHETDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9266364 | 0.91 | ACHE (0.32) | ACHEALDH1A1 | |
| SCHEMBL4775940 | 0.89 | ACHE (0.33) | ACHE | |
| SCHEMBL21083856 | 0.85 | KMT2A (0.32) | KMT2A | |
| Hydrochloric Acid SCHEMBL21083939 | 0.84 | KMT2A (0.31) | KMT2A | |
| SCHEMBL26435832 | 0.83 | ACHE (0.30) | ACHEALDH1A1KDM4E | |
| SCHEMBL13539597 | 0.82 | CNR1 (0.34) | — | |
| SCHEMBL879837 | 0.81 | CYP19A1 (0.32) | LMNAPDE3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 256 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118271246-A | Method for continuously preparing 2-butyl-1, 3-diazaspiro [4.4] nonane-1-en-4-one | 浙江华海药业股份有限公司 | 2024-07-02 | — | — | CN | claimed |
| EP-2417110-B1 | A ONE POT PROCESS FOR PREPARING 2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO [4, 4]NON-1-EN-4-ONE (IRBESARTAN) | CTX LIFE SCIENCES PVT LTD (IN) | 2014-05-07 | — | — | EP | claimed |
| EP-1885714-B1 | PROCESS FOR THE PREPARATION OF 2-ALKYL-1-((2'-SUBSTITUTED-BIPHENYL-4-YL)METHYL)-IMIDAZOLE, DIHYDROIMIDAZOLE OR BENZIMIDAZOLE DERIVATIVES | LEK PHARMACEUTICALS (SI) | 2014-01-15 | — | — | EP | claimed |
| US-7964737-B2 | Angiotensin II receptor antagonist; industrially viable, recoverable and reusable; Irbesartan | JUBILANT ORGANOSYS LIMITED (IN) | 2011-06-21 | — | — | US | claimed |
| EP-1853591-B1 | METHOD FOR OBTAINING A PHARMACEUTICALLY ACTIVE COMPOUND (IRBESARTAN) AND ITS SYNTHESIS INTERMEDIATE | INKE SA (ES) | 2009-11-25 | — | — | EP | claimed |
| US-20090216026-A1 | Novel synthesis of irbesartan | NISNEVICH GENNADY | 2009-08-27 | — | — | US | claimed |
| US-20090176849-A1 | Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl) Methyl)-imidazole, dihydroimidazole or benzimidazloe derivatives | LEK PHARMACEUTICALS, D.D. (SI) | 2009-07-09 | — | — | US | claimed |
| US-20090137648-A1 | PROCESS FOR THE PREPARATION OF IRBESARTAN HYDROCHLORIDE | CIPLA LIMITED (IN) | 2009-05-28 | — | — | US | claimed |
| US-20080214830-A1 | Process for Producing 2-(N-Butyl)-3-[[2'-(Tetrazol-5-Yl)Biphenyl-4-Yl]Methyl]-I,3-Diazaspiro[4,4] Non-1-En-4-One | JUBILANT ORGANOSYS LIMITED (IN) | 2008-09-04 | — | — | US | claimed |
| EP-1951714-A1 | PROCESS FOR PRODUCING 2-(N-BUTYL)-3-[[2'-(TETRAZOL-5-YL)BIPHENYL- 4-YL]METHYL]-1,3-DIAZASPIRO[4.4]NON-1-EN-4-ONE | Jubilant Organosys Limited (IN) | 2008-08-06 | — | — | EP | claimed |
| WO-2008012852-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTS | S.I.M.S. S.r.l. - SOCIETÀ ITALIANA MEDICINALI SCANDICCI (IT) | 2008-01-31 | — | — | WO | claimed |
| WO-2007013101-A1 | PROCESS FOR PRODUCING 2-(N-BUTYL)-3-[[2'-(TETRAZOL-5-YL)BIPHENYL- 4-YL]METHYL]-l,3-DIAZASPIRO[4.4] NON-1-EN-4-ONE | JUBILANT ORGANOSYS LIMITED (IN) | 2007-02-01 | — | — | WO | claimed |
| WO-2006125592-A2 | PROCESS FOR THE PREPARATION OF 2-ALKYL-1-((2'-SUBSTITUTED-BIPHENYL-4-YL)METHYL)-IMIDAZOLE, DIHYDROIMIDAZOLE OR BENZIMIDAZOLE DERIVATIVES | LEK PHARMACEUTICALS D.D. (SI) | 2006-11-30 | — | — | WO | claimed |
| EP-1546135-B1 | NOVEL SYNTHESIS OF IRBESARTAN | TEVA PHARMA (IL) | 2006-09-27 | — | — | EP | claimed |
| US-20050176794-A1 | Novel synthesis of irbesartan | TEVA PHARMACEUTICALS USA, INC. | 2005-08-11 | — | — | US | claimed |
| EP-1546135-A2 | NOVEL SYNTHESIS OF IRBESARTAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-06-29 | — | — | EP | claimed |
| EP-1509517-A2 | NOVEL SYNTHESIS OF IRBESARTAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-03-02 | — | — | EP | claimed |
| US-20040192713-A1 | Novel synthesis of irbesartan | TEVA PHARMACEUTICALS USA, INC. | 2004-09-30 | — | — | US | claimed |
| WO-2004065383-A2 | NOVEL SYNTHESIS OF IRBESARTAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-08-05 | — | — | WO | claimed |
| WO-2004007482-A2 | NOVEL SYNTHESIS OF IRBESARTAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-01-22 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214830-A1 | Process for Producing 2-(N-Butyl)-3-[[2'-(Tetrazol-5-Yl)Biphenyl-4-Yl]Methyl]-I,3-Diazaspiro[4,4] Non-1-En-4-One | CYP4B1, NONO, ENO1 | ACHE 1430/4885AGTR1 2594/4885LTB4R2 2243/4885 |
| US-20040192713-A1 | Novel synthesis of irbesartan | REN, AGTR1, AGTR2 | ACHE 4582/4885AGTR1 2/4885LTB4R2 997/4885 |
| US-20090176849-A1 | Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl) Methyl)-imidazole, dihydroimidazole or benzimidazloe derivatives | AGTR1, AGTR2, REN | ACHE 4471/4885AGTR1 1/4885LTB4R2 2505/4885 |
| US-20090216026-A1 | Novel synthesis of irbesartan | AGTR1, REN, AGTR2 | ACHE 4579/4885AGTR1 1/4885LTB4R2 1882/4885 |
| US-20050176794-A1 | Novel synthesis of irbesartan | AGTR1, REN, AGTR2 | ACHE 3593/4885AGTR1 1/4885LTB4R2 1579/4885 |
| US-20090137648-A1 | PROCESS FOR THE PREPARATION OF IRBESARTAN HYDROCHLORIDE | AGTR1, REN, AGTR2 | ACHE 4846/4885AGTR1 1/4885LTB4R2 4244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.