Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrogen Sulfide SCHEMBL16581552 | 0.86 | CA1 (0.61) | CA1CA2CA9SMN1; SMN2MAPT | |
| Tromethamine SCHEMBL1953963 | 0.85 | CA1 (0.46) | CA1CA2CA9SMN1; SMN2MAPT | |
| Tromethamine SCHEMBL16582071 | 0.85 | CA1 (0.46) | CA1CA2CA9CXCR2CXCR1 | |
| SCHEMBL2832043 | 0.84 | CA1 (0.63) | CA1CA2CA9SMN1; SMN2MAPT | |
| Tromethamine SCHEMBL23045289 | 0.82 | CA1 (0.46) | CA1CA2CA9CXCR2CXCR1 | |
| Biphenyl SCHEMBL710425 | 0.79 | CA1 (0.53) | CA1CA2CA9SMN1; SMN2MAPT | |
| Biphenyl SCHEMBL112616 | 0.77 | CA1 (0.54) | CA1CA2CA9SMN1; SMN2MAPT | |
| Tromethamine SCHEMBL5471107 | 0.77 | RXRA (0.41) | RXRARXRBALDH1A1TDP1MAPK1 | |
| Biphenyl SCHEMBL4512369 | 0.76 | CA1 (0.53) | CA1CA2CA9SMN1; SMN2MAPT | |
| SCHEMBL18560195 | 0.75 | CA1 (0.44) | CA1CA2CA9SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12232338-B2 | Low-voltage operation dual-gate organic thin-film transistors and methods of manufacturing thereof | CORNING INCORPORATED (US) | 2025-02-18 | — | — | US | claimed |
| EP-3079677-A1 | PHOTOPOLYMERIZABLE LIQUID COMPOSITION | Laboratoires Urgo (FR) | 2016-10-19 | — | — | EP | claimed |
| WO-2015087020-A1 | PHOTOPOLYMERIZABLE LIQUID COMPOSITION | LABORATOIRES URGO (FR) | 2015-06-18 | — | — | WO | claimed |
| CN-111045296-B | UV patternable polymer blend for organic thin film transistor | 康宁股份有限公司 | 2024-12-27 | — | — | CN | disclosed |
| US-20240334806-A1 | UV PATTERNABLE POLYMER BLENDS FOR ORGANIC THIN-FILM TRANSISTORS | CORNING INCORPORATED | 2024-10-03 | — | — | US | disclosed |
| CN-115373220-A | Resist composition | 曼彻斯特大学 | 2022-11-22 | — | — | CN | disclosed |
| CN-108351587-B | Resist composition | 曼彻斯特大学 | 2022-08-19 | — | — | CN | disclosed |
| CN-114879449-A | High-temperature-resistant polyimide photoresist and preparation method and application thereof | 江苏长进微电子材料有限公司 | 2022-08-09 | — | — | CN | disclosed |
| EP-3877787-A1 | CONTACT LENS WITH A SURFACE COATING, AND MANUFACTURING METHOD | Fachhochschule Kiel (DE) | 2021-09-15 | — | — | EP | disclosed |
| WO-2021066084-A1 | ULTRAVIOLET-CURABLE ORGANOPOLYSILOXANE COMPOSITION AND APPLICATION FOR SAME | ダウ・東レ株式会社 | 2021-04-08 | — | — | WO | disclosed |
| EP-3079677-A1 | PHOTOPOLYMERIZABLE LIQUID COMPOSITION | Laboratoires Urgo (FR) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015087020-A1 | PHOTOPOLYMERIZABLE LIQUID COMPOSITION | LABORATOIRES URGO (FR) | 2015-06-18 | — | — | WO | disclosed |
| US-7214530-B2 | Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2007-05-08 | — | — | US | disclosed |
| WO-2003093820-A1 | BIOMOLECULE DIAGNOSTIC DEVICES AND METHOD FOR PRODUCING BIOMOLECULE DIAGNOSTIC DEVICES | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2003-11-13 | — | — | WO | disclosed |
| US-20030207256-A1 | Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices | KIMBERLY-CLARK WORLDWIDE, INC. | 2003-11-06 | — | — | US | disclosed |