Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29073376 | 0.80 | SLC6A2 (0.38) | ALDH1A1AADAT | |
| SCHEMBL29073364 | 0.72 | GSK3B (0.38) | ALDH1A1 | |
| SCHEMBL5315126 | 0.68 | CYP1A2 (0.41) | ALDH1A1MEN1KMT2A | |
| SCHEMBL4064023 | 0.68 | SIRT1 (0.34) | SIRT1ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL3780079 | 0.66 | AADAT (0.58) | AADAT | |
| SCHEMBL29073342 | 0.66 | TRPA1 (0.39) | ALDH1A1AADATAOC3 | |
| SCHEMBL4254836 | 0.65 | ALDH1A1 (0.52) | ALDH1A1HSD17B10AADATMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6529063 | 0.65 | AADAT (0.39) | ALDH1A1AADATMEN1KMT2A | |
| SCHEMBL4064029 | 0.64 | AADAT (0.39) | AADATMEN1KMT2A | |
| SCHEMBL28558248 | 0.64 | PRKCQ (0.40) | KMT2AAOC3PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758863-A1 | TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES | AstraZeneca AB (SE) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123685-A1 | TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |