Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.55 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27717490 | 0.77 | NOTUM (0.46) | NPC1RAB9AL3MBTL1NOTUMTSHR | |
| SCHEMBL28048629 | 0.76 | NOTUM (0.47) | NPC1RAB9AL3MBTL1NOTUMTSHR | |
| SCHEMBL8024012 | 0.75 | OPRM1 (0.69) | HDAC8DPP4OPRM1OPRD1OPRK1 | |
| SCHEMBL2243756 | 0.73 | SLC7A5 (0.51) | HDAC8SLC7A5DPP4TYR | |
| SCHEMBL2243752 | 0.73 | SLC7A5 (0.51) | HDAC8SLC7A5DPP4TYR | |
| SCHEMBL28177422 | 0.72 | SLC7A5 (0.54) | HDAC8SLC7A5DPP4TYR | |
| SCHEMBL27761216 | 0.72 | NOTUM (0.57) | NPC1RAB9ANOTUMTSHR | |
| SCHEMBL5069267 | 0.72 | ALDH1A1 (0.50) | NPC1RAB9AL3MBTL1NOTUMTSHR | |
| Tyrosine SCHEMBL28027026 | 0.71 | SLC7A5 (0.75) | HDAC8SLC7A5ALOX15HIF1AHSD17B10 | |
| SCHEMBL1422055 | 0.70 | SLC7A5 (0.64) | HDAC8SLC7A5TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
| US-20030108946-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2003-06-12 | — | — | US | disclosed |
| US-20020022626-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | TANG PENG CHO (US) | 2002-02-21 | — | — | US | disclosed |
| US-6147106-A | USEFUL FOR THE TREATMENT OF DISEASES RELATED TO UNREGULATED PROTEIN KINASE SIGNAL TRANSDUCTION, INCLUDING CELL PROLIFERATIVE DISEASES SUCH AS CANCER, ATHEROSCLEROSIS, ARTHRITIS AND RESTENOSIS AND METABOLIC DISEASES SUCH AS | SUGEN, INC. (US) | 2000-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020022626-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | HDAC8 4568/4885SLC7A5 2357/4885NPC1 4748/4885 |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | HDAC8 4581/4885SLC7A5 2156/4885NPC1 4684/4885 |
| US-20030108946-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | HDAC8 4568/4885SLC7A5 2357/4885NPC1 4748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.