SCHEMBL536980

SCHEMBL536980

Nc1nc(Cl)c2c(n1)[N+]=CN2

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.34
CHUK O15111 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2127194 0.80
SCHEMBL8884479 0.77
SCHEMBL536868 0.77
SCHEMBL536879 0.73
SCHEMBL1025895 0.73 CCNA2 (0.35)
SCHEMBL4860847 0.69 CHEK1 (0.36)
SCHEMBL1023835 0.66 ADORA2A (0.48)
SCHEMBL1022892 0.66 ADORA2A (0.48)
SCHEMBL4058597 0.65
SCHEMBL996665 0.63 ALDH1A1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230340008-A1 BRIDGED NUCLEOSIDE AND NUCLEOTIDE USING SAME JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (JP) 2023-10-26 US claimed
WO-2023167094-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME 国立大学法人大阪大学 2023-09-07 WO claimed
US-20230124641-A1 CROSS-LINKED NUCLEOSIDE AND NUCLEOTIDE USING SAME JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (JP) 2023-04-20 US claimed
EP-4108670-A1 BRIDGED NUCLEOSIDE AND NUCLEOTIDE USING SAME OSAKA UNIVERSITY (JP) 2022-12-28 EP claimed
EP-4108262-A1 CROSS-LINKED NUCLEOSIDE AND NUCLEOTIDE USING SAME OSAKA UNIVERSITY (JP) 2022-12-28 EP claimed
CN-115135658-A Bridged nucleoside and nucleotide using the same 国立大学法人大阪大学 2022-09-30 CN claimed
US-20220127300-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME OSAKA UNIVERSITY (JP) 2022-04-28 US claimed
WO-2022004388-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME 国立大学法人大阪大学 2022-01-06 WO claimed
EP-3925965-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME Osaka University (JP) 2021-12-22 EP claimed
EP-3919501-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME Osaka University (JP) 2021-12-08 EP claimed
US-6034087-A VIRICIDE AGAINST HEPATITIS B CHONG KUN DANG CORP. (KR) 2000-03-07 US claimed
US-5925756-A Cyclopropane derivatives and method of preparing the same AJINOMOTO CO., INC. (JP) 1999-07-20 US claimed
EP-0869953-A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THEREOF CHONG KUN DANG CORP (KR) 1998-10-14 EP claimed
US-5777116-A Cyclopropane derivatives and method of preparing the same AJINOMOTO CO., INC. (JP) 1998-07-07 US claimed
US-5631259-A PURINE BASE DERIVATIVES FOR NUCLEOSIDES HOECHST AKTIENGESELLSCHAFT (DE) 1997-05-20 US claimed
WO-1996012716-A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THEREOF CHONG KUN DANG CORP. (KR) 1996-05-02 WO claimed
EP-0675123-A1 Cyclopropane derivatives and method of preparing the same Ajinomoto Co., Inc. (JP) 1995-10-04 EP claimed
US-5151426-A Treatment of aids BIOCHEM PHARMA INC. (CA) 1992-09-29 US claimed
EP-0167008-B1 1,4:3,6-DIANHYDRO-HEXITE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS Heinrich Mack Nachf. (DE) 1989-09-06 EP claimed
US-3935184-A Synthetic polyoxin type nucleosides SYNTEX (U.S.A.) INC. (US) 1976-01-27 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230340008-A1 BRIDGED NUCLEOSIDE AND NUCLEOTIDE USING SAME SLC29A1, SLC29A2, PNP DPP4 3015/4885CHUK 2656/4885
US-20230124641-A1 CROSS-LINKED NUCLEOSIDE AND NUCLEOTIDE USING SAME RNGTT, NUDT1, SLC29A2 DPP4 2094/4885CHUK 2597/4885
US-20220127300-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME NT5C3B, DUT, RNGTT DPP4 1842/4885CHUK 2919/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.