SCHEMBL5370244

SCHEMBL5370244

NC(=O)NC(C(=O)O)(c1ccccc1)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.45
KMT2A Q03164 1/20 0.45
CYP1A2 P05177 3/20 0.43
CYP3A4 P08684 2/20 0.43
RECQL P46063 2/20 0.43
TSHR P16473 2/20 0.43
POLB P06746 1/20 0.43
PARP1 P09874 1/20 0.43
CYP2C19 P33261 1/20 0.43
BLM P54132 1/20 0.43
PMP22 Q01453 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3904088 0.89 LMNA (0.45) MAPTKMT2ACYP1A2POLBHDAC3
SCHEMBL4231541 0.88 MAPT (0.50) MAPTKMT2ACYP1A2CYP3A4RECQL
SCHEMBL3904092 0.83 KMT2A (0.40) MAPTKMT2ACYP1A2CYP3A4RECQL
SCHEMBL10741457 0.79 KCNN4 (0.44) MAPTKMT2ACYP1A2CYP3A4RECQL
SCHEMBL9874721 0.79 MAPT (0.45) MAPTKMT2ACYP1A2CYP3A4RECQL
SCHEMBL10950580 0.79 CYP1A2 (0.55) MAPTKMT2ACYP1A2CYP3A4RECQL
SCHEMBL2462307 0.78 MAPT (0.48) MAPTKMT2ACYP1A2CYP3A4RECQL
SCHEMBL28250046 0.78 POLB (0.49) MAPTKMT2ACYP1A2CYP3A4RECQL
Bromide SCHEMBL10946161 0.77 CYP1A2 (0.54) MAPTKMT2ACYP1A2CYP3A4RECQL
SCHEMBL8380156 0.75 CYP1A2 (0.48) MAPTKMT2ACYP1A2CYP3A4RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3551182-A1 TOPICAL PHARMACEUTICAL COMPOSITION CONTAINING PHENYTOIN AND A (CO -)AN ALGESIC FOR THE TREATMENT OF CHRONIC PAIN TOPICAL INNOVATIONS B.V. (NL) 2019-10-16 EP claimed
WO-2018106108-A1 TOPICAL PHARMACEUTICAL COMPOSITION CONTAINING PHENYTOIN AND A (CO -)AN ALGESIC FOR THE TREATMENT OF CHRONIC PAIN KEPPEL HESSELING, Jan Marius (NL) 2018-06-14 WO claimed
US-20130005786-A1 THERAPEUTIC INVENTION KAPOOR RAJU (GB) 2013-01-03 US claimed
US-20070244074-A1 Stable parenteral formulation of fosphenytoin sodium STRIDES ARCOLAB LIMITED (IN) 2007-10-18 US claimed
EP-3551182-B1 TOPICAL PHARMACEUTICAL COMPOSITION CONTAINING PHENYTOIN AND A (CO -)AN ALGESIC FOR THE TREATMENT OF CHRONIC PAIN TOPICAL INNOVATIONS B V (NL) 2025-03-19 EP disclosed
EP-3551166-B1 TOPICAL PHENYTOIN FOR USE IN THE TREATMENT OF PERIPHERAL NEUROPATHIC PAIN TOPICAL INNOVATIONS B V (NL) 2024-08-21 EP disclosed
US-20240033223-A1 FOSPHENYTOIN SODIUM SOLID COMPOSITION, LYOPHILIZATION METHOD, AND USE OF FOSPHENYTOIN SODIUM SOLID COMPOSITION FIDELITY BIOPHARMA CO. 2024-02-01 US disclosed
EP-4257120-A1 FOSPHENYTOIN SODIUM SOLID COMPOSITION, LYOPHILIZATION METHOD, AND USE OF FOSPHENYTOIN SODIUM SOLID COMPOSITION Sichuan Credit Pharmaceutical Co., Ltd (CN) 2023-10-11 EP disclosed
CN-114588116-A Solid composition of fosphenytoin sodium, freeze-drying method and application thereof 四川科瑞德制药股份有限公司 2022-06-07 CN disclosed
US-11285099-B2 Topical phenytoin for use in the treatment of peripheral neuropathic pain TOPICAL INNOVATIONS B.V. (NL) 2022-03-29 US disclosed
US-11147799-B2 Topical pharmaceutical composition containing phenytoin and a (co-) analgesic for the treatment of chronic pain Keppel Hesselink, Jan Marius (NL) 2021-10-19 US disclosed
US-20200276106-A1 TOPICAL PHENYTOIN FOR USE IN THE TREATMENT OF PERIPHERAL NEUROPATHIC PAIN TOPICAL INNOVATIONS B.V. (NL) 2020-09-03 US disclosed
US-6432923-B1 ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES NOVARTIS AG (CH) 2002-08-13 US disclosed
US-6407065-B1 PREVENT CELL ADHESION; ANTIINFLAMMTORY AGENTS, RESPIRATORY SYSTEM DISORDERS NOVARTIS AG (CH) 2002-06-18 US disclosed
US-6365619-B1 CYCLIC OLIGOPEPTIDE VCAM-1 INHIBITOR; (S)-.BETA.-(3-METHOXYPROPYL) ((4-((2-METHYLPHENYLAMINOCARBONYLAMINO)-PHENYL) ACETYL)AMINO)ACETYL-AMINO-3,4-DIMETHOXY-BENZENEPROPANOIC ACID NOVARTIS AG (CH) 2002-04-02 US disclosed
WO-2001042192-A2 VLA-4 INTEGRIN ANTAGONISTS NOVARTIS AG (CH) 2001-06-14 WO disclosed
EP-0726761-B1 MICROPARTICULAR PHARMACEUTICAL COMPOSITIONS IN MICELLAR FORM ISOMED INC (US) 2001-01-10 EP disclosed
EP-1049665-A1 VLA-4 ANTAGONISTS Novartis AG (Novartis SA) (Novartis Inc.) (CH) 2000-11-08 EP disclosed
WO-1999037605-A1 VLA-4 ANTAGONISTS NOVARTIS AG (CH) 1999-07-29 WO disclosed
US-5858398-A MICROPARTICLES CONTAINING ACTIVE AGENT, MIXTURE OF PHOSPHOLIPIDS, MIXTURE OF NONIONIC SURFACTANTS, STEROL SUSPENDED IN FATTY ACID ISOMED INC. (US) 1999-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070244074-A1 Stable parenteral formulation of fosphenytoin sodium TPMT, TTPA, TYMP MAPT 424/4885KMT2A 1025/4885CYP1A2 458/4885
US-20240033223-A1 FOSPHENYTOIN SODIUM SOLID COMPOSITION, LYOPHILIZATION METHOD, AND USE OF FOSPHENYTOIN SODIUM SOLID COMPOSITION FOS, CA3, SORD MAPT 190/4885KMT2A 2038/4885CYP1A2 908/4885
US-20130005786-A1 THERAPEUTIC INVENTION AQP4, PMP22, NHERF1 MAPT 1803/4885KMT2A 2062/4885CYP1A2 2721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.