Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 4/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | SI | P14410 | 4/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | F12 | P00748 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871 | 0.83 | MEN1 (0.30) | KMT2A | |
| SCHEMBL1395480 | 0.81 | POLB (0.54) | POLBMAPK1ATMKMT2AALDH1A1 | |
| SCHEMBL5379722 | 0.79 | MAPK1 (0.46) | POLBMAPK1ATMKMT2AALDH1A1 | |
| SCHEMBL3181930 | 0.78 | ALDH1A1 (0.32) | ALDH1A1MAPTHTT | |
| SCHEMBL5371444 | 0.74 | POLB (0.43) | POLBMAPK1ATMKMT2AALDH1A1 | |
| SCHEMBL2824611 | 0.74 | SLC9A1 (0.41) | POLBMAPK1ATMKMT2AALDH1A1 | |
| SCHEMBL44479 | 0.74 | SLC9A1 (0.41) | POLBMAPK1ATMKMT2AALDH1A1 | |
| SCHEMBL1941412 | 0.74 | SLC9A1 (0.41) | POLBMAPK1ATMKMT2AALDH1A1 | |
| SCHEMBL5332213 | 0.73 | SLC9A1 (0.40) | POLBMAPK1ATMKMT2AALDH1A1 | |
| SCHEMBL28752327 | 0.71 | POLB (0.70) | POLBMAPK1ATMKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288661-B2 | Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-10-30 | — | — | US | claimed |
| US-20070123581-A1 | Process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-05-31 | — | — | US | claimed |
| US-20070093663-A1 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof. | LES LABORATOIRES SERVIER (FR) | 2007-04-26 | — | — | US | claimed |
| WO-2005066198-A1 | METHOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2005-07-21 | — | — | WO | claimed |
| EP-1420030-A2 | Method for synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril | Les Laboratoires Servier (FR) | 2004-05-19 | — | — | EP | claimed |
| EP-1420029-A2 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | LES LABORATOIRES SERVIER (FR) | 2004-05-19 | — | — | EP | claimed |
| US-7288661-B2 | Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-10-30 | — | — | US | disclosed |
| US-7279583-B2 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof | LES LABORATOIRES SERVIER (FR) | 2007-10-09 | — | — | US | disclosed |
| US-20070123581-A1 | Process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-05-31 | — | — | US | disclosed |
| US-20070093663-A1 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof. | LES LABORATOIRES SERVIER (FR) | 2007-04-26 | — | — | US | disclosed |
| EP-1420030-A2 | Method for synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril | Les Laboratoires Servier (FR) | 2004-05-19 | — | — | EP | disclosed |
| EP-1420029-A2 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | LES LABORATOIRES SERVIER (FR) | 2004-05-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093663-A1 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof. | QDPR, REN, ACE | POLB 2909/4885MAPK1 1744/4885ATM 4395/4885 |
| US-20070123581-A1 | Process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | CYP2S1, TPH1, AGTR1 | POLB 3241/4885MAPK1 753/4885ATM 3947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.